Amiodarone Toxicity Presenting with Acute Onset of Systemic Inflammatory Response Syndrome and Multiorgan Failure Mimicking Sepsis

Kugasia, Irfanali R; Ijaz, Mohsin; Khan, Ahsan; Jasti, Yashwanth

doi:10.12659/ajcr.926929

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Blood cultures and viral panels yielded no definitive source of infection. This aligns with another documented instance wherein a multi-systemic inflammatory response was observed in a patient following IV amiodarone supporting this hypothesis [ 7 ]. In addition, this patient was found to have underlying cirrhosis as demonstrated on a liver ultrasound only after amiodarone was discontinued.…”

Section: Discussionsupporting

confidence: 92%

Acute Multi-Organ Toxicity During 24-Hour Dosing of Intravenous Amiodarone: A Case Report

Liwag¹,

Wong²,

Martinez³

et al. 2022

Cureus

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We present a unique case of a 60-year-old male with congestive heart failure who was admitted for a pre-syncopal episode and found to be in atrial fibrillation with rapid ventricular response (RVR). In order to effectively rate control the patient, he was administered an amiodarone bolus and intravenous (IV) infusion over 24 hours, along with a single oral 200 mg dose the following day. The patient subsequently developed acute hepatotoxicity along with features of acute kidney injury (AKI), pulmonary distress, and leukocytosis. After ruling out other etiologies for acute liver, pulmonary, and kidney injury, amiodarone-induced multi-organ toxicity was suspected and amiodarone was discontinued. Within hours of amiodarone discontinuation, the patient’s clinical status and organ function improved remarkably. In the setting of a patient being treated with IV amiodarone and presenting with sudden signs of dyspnea, acute elevation of transaminases and AKI within one to two days of initial dosing, acute amiodarone-induced organ toxicity should be considered.

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Section: Discussionsupporting

confidence: 92%