Amiodarone induced pulmonary toxicity

Hudec, Martin; Vysočanová, Petra; Brázdil, Vojtěch; Poloczek, Martin; Hetmer, Martin; Little, J. Samuel; Doubková, Martina; Kala, Petr

doi:10.36290/vnl.2021.116

Cited by 2 publications

(1 citation statement)

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“…In IRI, amiodarone not only acts as an antiarrhythmic but also protects cardiomyocytes [ 15 ]. After the occurrence of AMI, the permeability of the myocardial cell membrane increases, causing the intracellular CK-MB and cTnI to leak out, resulting in an increase in the concentration of CK-MB and cTnI in the blood of patients, so the levels of the two are more sensitive indicators to reflect the degree of myocardial injury [ 16 ]. Animal experiments have shown that amiodarone can reduce serum CK-MB and cTnI levels in rats with myocardial ischemia-reperfusion, suggesting that it can alleviate acute myocardial ischemia-reperfusion injury in rats [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Amiodarone on Reperfusion Arrhythmia in Patients of Acute Myocardial Infarction with Percutaneous Coronary Intervention Treatment

Leng

Sun

Peng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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With the development and popularity of percutaneous coronary intervention (PCI), ischemia-reperfusion injury (IRI) has attracted more and more clinical attention. Reperfusion arrhythmia (RA), one of the common manifestations during and after PCI, can affect the postoperative cardiac function of patients with acute myocardial infarction (AMI). Therefore, effective intervention on RA has important clinical significance. This study observed the effect of amiodarone on reperfusion arrhythmia (RA) after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) and explored its possible mechanism. The results showed that amiodarone had good clinical efficacy in the prevention of RA in patients with AMI after PCI, and it could reduce the levels of serum IL-6, hs-CRP, CK-MB, and cTnI in patients and reduce the damage caused by reperfusion, thereby reducing the occurrence of RA.

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Section: Discussionmentioning

confidence: 99%