Amiodarone-Induced Cirrhosis: A Well Known Underrecognized Complication

Drug-induced Fatty Liver Disease: Pathogenesis and Treatment

“…Various other studies have confirmed the role of amiodarone in the induction of liver cirrhosis, with possible fatal outcomes. [30][31][32] Nevertheless, these adverse effects were found to be rare, with an incidence of 1-3%. A long-term surveillance for liver toxicity in high-risk patients using amiodarone has been suggested by numerous researchers.…”

“…A long-term surveillance for liver toxicity in high-risk patients using amiodarone has been suggested by numerous researchers. 30,31,33 Most drugs capable of causing steatosis and steatohepatitis are known to have cationic amphiphilic structure. 34 These drugs are divided into three groups, including drugs that cause steatosis and steatohepatitis independently, such as amiodarone and perhexiline, drugs that can accelerate latent metabolic dysfunction-associated steatohepati-tis (MASH), such as tamoxifen, and drugs that may cause sporadic events of steatosis/steatohepatitis, such as carbamazepine.…”

“…A long-term surveillance for liver toxicity in high-risk patients using amiodarone has been suggested by numerous researchers. 30 , 31 , 33 …”