Amiodarone in the Wolff-Parkinson-White syndrome

Wellens, Hein J.J.; Bär, Frits W.; Wesdorp, Jan C.; Dohmen, Henk J.; Düren, Donald R.

doi:10.1016/0002-9149(76)90776-1

Cited by 4 publications

(3 citation statements)

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“…It lengthens the transnodal conduction time as well as the effective and functional refractory periods of the node. As opposed to amiodarone (Touboul et al, 1975;Wellens et al, 1976;Waleffe et al, 1978), it has no effect on anterograde conduction over the intraventricular conduction system, on ventricular muscle, and accessory pathways.…”

Section: Discussionmentioning

confidence: 99%

“…Amiodarone has been reported to be an effective antiarrhythmic agent for different types of arrhythmia (Coumel et al, 1974;Rosenbaum et al, 1974;Touboul et al, 1975;Rosenbaum et al, 1976;Wellens et al, 1976;Waleffe et al, 1978). Sideeffects however have limited wide acceptance of the drug in clinical practice (Geerts, 1971;Verin et al, 1971;Babel and Stangos, 1973;Pritchard et al, 1975;Burger et al, 1976).…”

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confidence: 99%

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Electrophysiological effects of L 9394 (benzoyl-indolizine) in man.

Waleffe¹,

Bordalo²,

Bruninx³

et al. 1979

Heart

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The electrophysiological effects of L 9394 (benzoyl-indolizine), a substance chemically related to amiodarone, but devoid of iodine atoms, were investigated by programmed electrical stimulation of the heart in 12 patients with various forms of tachycardia. Four subjects had electrocardiographic evidence of the WPW syndrome and episodes of circus movement tachycardia. Paroxysmal supraventricular tachycardia, confined to the atrioventricular (AV) node, was found in 3 patients. In 2 cases, where a short PR interval was present, the main complaint was the occurrence of paroxysmal atrial fibrillation. In the remaining 3 instances, the arrhythmia consisted of slow ventricular tachycardia (1 case), supraventricular tachycardia of the focal type (1 case), and episodes of primary ventricular fibrillation, not related to acute myocardial ischaemia (1 case). L 9394 injected intravenously was seen to lengthen the transnodal conduction time as well as the effective and functional refractory periods of the node. Similar effects were found on the retrograde VA pathway. The drug had no action on the infra-Hisian conduction system, on the refractory periods of ventricular muscle, or on the refractory periods of accessory bypasses. The drug was injected during an episode of tachycardia in 6 cases with reproducible supraventricular re-entrant tachycardia. Three had a tachycardia circuit confined to the node. In those instances, the drug had beneficial effects (slowing and interruption of tachycardia, decrease or abolition of echo zone; loss of ability to induce tachycardia). In the other 3 cases, an accessory pathway was incorporated in the circuit. L 9394 interrupted the tachycardia in 2 instances (by anterograde AV block), but failed to protect all 3 patients against reinitiation of tachycardia by premature stimuli. It is concluded that L9394 does not share all the pharmacological properties of amiodarone and will not replace it in all its indications.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Electrophysiological effects of L 9394 (benzoyl-indolizine) in man.

Waleffe¹,

Bordalo²,

Bruninx³

et al. 1979

Heart

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“…Amiodarone (Cordarone, Labaz), a benzfuran derivative, was introduced as an antianginal agent in 1967 [1], Extensive clinical experience outside the United States with the drug has shown its successful use in the pro phylaxis and treatment of a variety of supra ventricular and ventricular arrhythmias [2][3][4][5][6][7][8]. It is currently under investigation in the United States.…”

Section: Introductionmentioning

confidence: 99%

Functional Significance of Chronotropic Response during Chronic Amiodarone Therapy

Rod

Shenasa

1984

Cardiology

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Amiodarone, a potent antiarrhythmic agent, has been shown to depress sinus node function. Therefore, this study was undertaken to assess the effect of chronic amiodarone therapy on heart rate during graded exercise testing. 13 patients treated with amiodarone for ventricular arrhythmias were administered symptom-limited graded exercise testing before and 12 weeks after drug therapy. None of the patients had prior evidence of sinus node dysfunction. The mean resting heart rate (beats per minute; bpm) before and after amiodarone therapy was 75 ± (SD) 13 versus 60 ± 7 bpm, respectively (p < 0.005), and the maximal heart rate was 135 ± 30 versus 109 ± 24 bpm (p < 0.005). However, the change in heart rate from rest to maximum exercise (heart rate reserve) was not affected by the drug. Heart rate measured at comparable exercise levels before and during amiodarone therapy was 124 ± 25 versus 104 ± 31 (p < 0.025). There was no change in the systolic blood pressure readings at these respective measured heart rates. Estimated maximal functional capacity before and after drug therapy was 4.9 ± 1.8 versus 4.7 ± 2.2 METs (p = NS). In conclusion, chronic amiodarone therapy significantly decreases heart rate at rest and during exercise without altering systolic blood pressure and functional capacity.

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Mechanisms of atrioventricular junctional tachycardia

Barold

Coumel

1977

The American Journal of Cardiology

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Amiodarone in the Wolff-Parkinson-White syndrome

Cited by 4 publications

References 0 publications

Electrophysiological effects of L 9394 (benzoyl-indolizine) in man.

Electrophysiological effects of L 9394 (benzoyl-indolizine) in man.

Functional Significance of Chronotropic Response during Chronic Amiodarone Therapy

Mechanisms of atrioventricular junctional tachycardia

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