Biochemical Pharmacology volume 82, issue 9, P1234-1249 2011 DOI: 10.1016/j.bcp.2011.07.090 View full text
Elena Piccoli, Matteo Nadai, Carla Mucignat Caretta, Valeria Bergonzini, Claudia Del Vecchio, Huy Riem Ha, Laurent Bigler, Daniele Dal Zoppo, Elisabetta Faggin, Andrea Pettenazzo, Rocco Orlando, Cristiano Salata, Arianna Calistri, Giorgio Palù et al.

Abstract: Patients treated with amiodarone accumulate lysobisphosphatidic acid (LBPA), also known as bis(monoacylglycero)phosphate, in airway secretions and develop in different tissues vacuoles and inclusion bodies thought to originate from endosomes. To clarify the origin of these changes, we studied in vitro the effects of amiodarone on endosomal activities like transferrin recycling, Shiga toxin processing, ESCRT-dependent lentivirus budding, fluid phase endocytosis, proteolysis and exosome secretion. Furthermore, s…

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