Aminothiaindanone as an Accessible Scaffold for a Three-Point Chemical Diversity

Abstract

Aminothiaindanone heterocycle appears to be a scaffold of interest in medicinal chemistry. In order to increase the chemical diversity in this series, we explored the introduction of three-point chemical diversity on the cyclopenta[b]thiophen-4-one scaffold. About thirty newly functionalized thiophene-containing bicycles have been obtained using various chemical reactions, paving the way for novel possibilities in medicinal chemistry projects.