Aminosalicylic Acid

Hassan, M. M. A.; Jado, Ahmad I.; Zubair, Muhammad

doi:10.1016/s0099-5428(08)60636-x

Cited by 6 publications

(1 citation statement)

References 20 publications

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“…In the solid phase, PAS has an absorption band in the IR spectrum due to NH 2 vibrations at 3520 cm −1 , a further band at 3400 cm −1 due to the NH 2 and/or OH groups and a strong, characteristic band at 1630 cm −1 due to the stretching vibration of C = O [16] . The spectrum of pure PAS presented these characteristic signals at 3496 cm −1 for the NH 2 vibration, signals at 3388 cm −1 for the NH 2 and/or OH groups and a band at 1652 cm −1 for the C = O group (Figure 7a).…”

Section: Resultsmentioning

confidence: 99%

Preparation and characterisation of novel spray-dried nano-structured para-aminosalicylic acid particulates for pulmonary delivery: impact of ammonium carbonate on morphology, chemical composition and solid state

Gad

Tajber

Corrigan

et al. 2012

Journal of Pharmacy and Pharmacology

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Objectives The objective of this work was to spray dry p‐aminosalicylic acid (PAS) and its ammonium salt and to investigate the impact of the pore‐forming agent, ammonium carbonate (AC), on the morphological, aerodynamic and physicochemical properties of the resulting powders. Methods Microparticles were prepared by spray drying from ethanol/water solvent systems. Their solid‐state properties were evaluated by scanning electron microscopy, powder X‐ray diffraction, differential scanning calorimetry, thermogravimetric analysis and in‐vitro deposition, using the twin impinger. Key Findings The physicochemical properties of PAS were altered on spray drying with AC and a new solid state was produced. The solution composition impacted on the morphology of the resulting powders, which ranged from irregular crystal agglomerates to spherical crystal clusters and porous microparticles. The chemical composition, structure and morphology were dependent on process inlet temperature, low inlet temperatures resulting in a novel solid of stoichiometry; PAS : ammonia : water, 2 : 1 : 0.5. At higher temperatures pure PAS was obtained. In‐vitro deposition studies showed an increase in emitted dose from spray dried drug, relative to the micronised PAS. Conclusions Under appropriate process conditions AC interacts with the acidic PAS, resulting in the formation of a novel solid‐state drug phase. Spray‐dried PAS powders have potential for pulmonary delivery.

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Section: Resultsmentioning

confidence: 99%