Aminophylline hypersensitivity apparently due to ethylenediamine

Terzian, C. G.; Simon, P

doi:10.1016/s0196-0644(05)80895-9

Cited by 13 publications

(10 citation statements)

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“…The asthma drug aminophylline is a complex of ethylenediamine and theophylline. Systemic reactions have been reported after use of this preparation, and have been explained as hypersensitivity reactions to ethylenediamine (14)(15)(16). Ethylenediamine has also been used as a stabilizer in antibiotic and corticosteroid creams, and has been a common cause of allergic reactions (17).…”

Section: Discussionmentioning

confidence: 99%

Activation and cross‐reactivity pattern of a new allergen in adhesive plaster

Bergendorff

Hansson

2000

Contact Dermatitis

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N,N'-disalicylidene-1,2-diaminopropane is a copper inhibitor present in some adhesive plasters, rubber products and gasoline. Upon contact with water it is hydrolyzed to salicylaldehyde and 1,2-diaminopropane. All patients in this study showed positive patch-test reactions to N,N'-disalicylidene-1,2-diaminopropane, and also to 1,2-diaminopropane and ethylenediamine. None reacted to salicylaldehyde. Patch testing with different N,N'-disalicylidene-derivatives showed localization of the amino groups in positions 1 and 2 to be a prerequisite of cross-reactivity to 1,2-diaminopropane and ethylenediamine. An extraction procedure and a high-performance liquid chromatography (HPLC) method for the analysis of adhesive plasters is described. Studies of the hydrolysis of the copper inhibitor at physiological pH showed rapid formation of 1,2-diaminopropane under biomimetic conditions.

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Section: Discussionmentioning

confidence: 99%

Activation and cross‐reactivity pattern of a new allergen in adhesive plaster

Bergendorff

Hansson

2000

Contact Dermatitis

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“…In addition, an entire family of antihistamines is derived from EDA (hydroxyzine, pyrilamine and tripelenamine), and some cross‐reactions have been reported systematically and topically 4,18 . Although rare, the allergic reactions to these EDA derivatives may result in significant morbidity 17 …”

Section: Introductionmentioning

confidence: 99%

Sensitization to ethylenediamine dihydrochloride in patients with contact dermatitis in northeastern Italy from 1996 to 2021

Piapan,

Belloni Fortina,

Giulioni

et al. 2023

Contact Dermatitis

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BackgroundEthylenediamine dihydrochloride is a versatile aliphatic amine found in numerous medications and industrial compounds and is a known sensitiser. The sensitisation prevalence is affected by geographical and socio‐cultural factors.ObjectivesThe objectives are to analyse the temporal trend of sensitisation to ethylenediamine dihydrochloride in northeastern Italy and to investigate associations with occupations.MethodsBetween 1996 and 2021, 30 629 patients with suspected allergic contact dermatitis were patch tested with the Triveneto baseline series. Individual characteristics were collected through a standardised questionnaire.ResultsThe overall prevalence of ethylenediamine dihydrochloride sensitisation was 1.29% with percentages similar in both sexes. We observed a significant decreasing trend over time (p < 0.001), yielding a sensitisation prevalence <1% in recent years. Among departments, residence in Pordenone area was protective for sensitisation. No significant associations were observed with specific occupations. We found significant associations between ethylenediamine dihydrochloride sensitisation and being 26–35 years old (odds ratio [OR], 1.47; 95% confidence interval [CI]: 1.05–2.08), and sensitisation for many haptens, such as paraben mix (OR, 5.3; 95% CI: 3.3–8.5), epoxy resin (OR, 5.1; 95% CI: 3.0–8.7), neomycin sulphate and mercaptobenzothiazole.ConclusionsOur study showed a downward time trend of ethylenediamine dihydrochloride sensitisation in northeastern Italian population and pointed to an update of the Triveneto baseline series.

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“…Unlike theophylline with its low solubility, aminophylline has mostly been used as an injectable treatment and there have been various reports on its efficacy 1–5 . However, aminophylline is a mixture of ethylenediamine sodium and theophylline, and allergic reactions to the ethylenediamine component, including urticaria and dyspnoea, have been reported 7–10 . Intravenously administered theophylline (IAT) was developed in 2000.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5] However, aminophylline is a mixture of ethylenediamine sodium and theophylline, and allergic reactions to the ethylenediamine component, including urticaria and dyspnoea, have been reported. [7][8][9][10] Intravenously administered theophylline (IAT) was developed in 2000. Unlike aminophylline, solubilized theophylline is not combined with ethylenediamine and it is, therefore, expected to have fewer side-effects.…”

Section: Introductionmentioning

confidence: 99%