Aminomethylation of Thiourea with Formaldehyde and Cyclic Amines

Novel semicarbazone-based α-amidoalkylating reagents: general synthesis and reactions with <em>H</em>-, <em>O</em>-, <em>S</em>-, <em>N</em>-, and <em>P</em>-nucleophiles

“…Commonly, electrophilic amidoalkylating reagents are based on carboxamides and carbamates [1][2][3]. Their preparation from other amides, e.g., ureas [24][25][26][27], thioureas [28][29][30], guanidines [31][32][33], thio-and dithiocarbamates [34][35][36], amides of various oxoacids of sulfur [37,38] and phosphorus [39,40] has been much less studied. To the best of our knowledge, there are no reports on preparation and application of semicarbazide-based amidoalkylating reagents.…”