Aminoglycosides decrease glutathione peroxidase-1 activity by interfering with selenocysteine incorporation.

Abstract

On page 20329 in the Abstract, the sentence beginning on line 10 should read as follows: "Here, we report that, in the absence of other components, TDP-43 spontaneously forms aggregates bearing remarkable ultrastructural similarities to TDP-43 deposits in degenerating neurons of ALS and FTLD-U patients." VOLUME 281 (2006) The following "Acknowledgment" was inadvertently omitted from the manuscript: "We thank Dr. Muniswamy Madesh for critical reading of the manuscript." VOLUME 281 ( ADDITIONS AND CORRECTIONS This paper is available online at www.jbc.orgWe suggest that subscribers photocopy these corrections and insert the photocopies in the original publication at the location of the original article. Authors are urged to introduce these corrections into any reprints they distribute. Secondary (abstract) services are urged to carry notice of these corrections as prominently as they carried the original abstracts.

Human αB-Crystallin Mutation Causes Oxido-Reductive Stress and Protein Aggregation Cardiomyopathy in Mice

“…(C, D) At 6 months, protein expression for GPx-1 is unchanged but catalase was increased in hR120GCryAB High animals compared with NTg, hCryAB Tg and hR120GCryAB Low Tg animals. Moderate increase in GPx activity (panel A) without a commensurate increase in GPx protein expression may reflect the translational limitations of available selenium, which is not standardized in chows, and/or of the translational cofactors required for selenoprotein synthesis (Handy et al, 2006). Each lane represents an individual animal (3 animals/group).…”

High Error Rates in Selenocysteine Insertion in Mammalian Cells Treated with the Antibiotic Doxycycline, Chloramphenicol, or Geneticin

“…These compounds, including G418, have been used to rescue the p53 tumor suppressor protein by suppressing a premature stop codon in a mutated form of p53 (13). G418 has also been shown to cause mistranslation of GPx1 by inserting Arg at the UGA-Sec codon in mammalian cells (14). Dox is a tetracycline that also binds to the small ribosomal subunit but, unlike aminoglycosides, blocks the attachment of aminoacyl-tRNA to the A-site (10,11).…”

On the importance of selenium and iodine metabolism for thyroid hormone biosynthesis and human health

“…The potential interaction of Se supple-mentation with the regular medications has often not been characterised, as mentioned above for AIDS and antiviral therapy. Moreover, potential interference with other widespread used pharmaceuticals like statins [31] or aminoglycoside antibiotics [32] have been described in vitro but are at present of unknown importance for Se metabolism in humans.…”