“…Although not shown thus far, it has been suggested that the genes responsible for the widespread resistance to aminoglycoside antibiotics in pathogens originate from soil bacteria, notably the actinomycetes, which are the most prominent aminoglycoside producers, and that the resistance genes were spread to other bacteria via horizontal gene transfer (Benveniste and Davies, 1973;Marshall et al, 1998;Grohmann et al, 2003). Several AICEs are able to mobilise chromosomal markers (Moretti et al, 1985;Hopwood et al, 1984;Brown et al, 1988b;Vrijbloed, 1996;Smokvina et al, 1988;Bibb et al, 1981), suggesting that they may play an important role in horizontal gene transfer and evolution of genome plasticity.…”