Aminocarbonsäureester des Furans, Thiophens und Thiazols

Abstract

Nr. 4119431 Da.nn. 419 8) 2 -O x o-6 -ni e t h yl -p i p e r i d i 11, 2 -M e t h y 1 -p i p e r i d o n -(6) , L a c t a ni d e r 6-A m i n o -c a p r o n s a u r e (VI). 2 g des ungesattigten Lactanis V wurden in Athanol mit PtO, als Katalysator hydriert. I n 3 Stdn. wurden 460 ccni H, aufgenommen. Das gesattigte Lactam lie13 sich atis Essigester in glanzenden Krystallblattchen gewinnen. Schmp. 84-8505). CeH,lOX (113). Uer. C 63.67, H 9.80. Gef. C (33.78, 63.62, €I 9.64, 9.60. 9) 6 -A m i n oc a p r o n s a u r e. 3 g P i p e r i d o n V I wurden niit 20 g Bariunihydroxyd in 200 ccni Wasser 4 Stdn. auf dem Danipfbad gehalten. Danach war-fast alles in Losung gegaiigen. Vom Barium wurde mit verd. Schwefelsaure befreit und eingedampft ;cler Ruckstand niit Methanol ausgezogen. Es hinterblieben nach deni Verdanipfen 2.9 g einer aus Methanol-Ather gut krystallisierenden Aminosaure vom Schmp 172O.

Electron-Rich Amino Heterocyclesfor Regiospecific Synthesis of Trifluoro­methyl-ContainingFused Pyridines

“…8a In summary, we propose a useful and convenient procedure for the synthesis of CF 3 -containing fused pyridines in high yield with a vast variety of combinatorial modifications of fragments in the final structures. Commercially unavailable starting amino heterocycles (5-aminopyrazoles 1, 17 5-aminoisooxazoles 8, 18 5-aminouracyles 9, 19 2-aminofuran 10, 20 2-aminothiophenes 11 21 and 1,2,3,3-tetramethyl-2,3dihydro-1H-6-indolylamine 20 22 ) were prepared according to the literature.…”

Photochemical Behavior of Iodoheterocyclic Derivatives in the Presence of Electron-Poor Olefins

“…[11] 2-Iodo-5-nitrothiophene (1c) was obtained from 2-iodothiophene by reaction with nitric acid and Ac 2 O. [12] 5-Bromofuran-2-carbaldehyde (1d) was prepared from furan-2-carbaldehyde by reaction with bromine in dichloromethane. [13] Photochemical Reactions of 1a-d with Electron-Poor Olefins -General Procedure: The iodoheterocyclic derivative 1a-d (0.4 mmol) was dissolved in acetonitrile (70 mL) containing the olefin 2a-e (3 g).…”

Photochemical Behavior of Iodoheterocyclic Derivatives in the Presence of Electron-Poor Olefins

“…-Elemental analyses were carried out using a Carlo Erba 1106 elemental analyzer. [12] 5-Bromofuran-2-carbaldehyde (1d) was prepared from furan-2-carbaldehyde by reaction with bromine in dichloromethane. [9] 2-Iodothiophene was obtained by reaction of thiophene with iodine and HgO.…”