Amino sulfonic acids, peptidosulfonamides and other related compounds

3‐Carboxy‐/3‐Aminobicyclo[1.1.1]pentane‐Derived Sulfonamides and Sulfonyl Fluorides – Advanced Bifunctional Reagents for Organic Synthesis and Drug Discovery

“…On the other hand, organosulfur derivatives have been essential reagents in organic synthesis for many decades;, recent years have witnessed several seminal discoveries which have altered landscape of this field significantly and drew much attention to these compounds (Scheme ). In particular, sulfinates were re‐introduced by Baran and co‐workers in early 2010s as the reagents for late‐stage C–H functionalization .…”

Synthesis of Functionalized Bridged Bicyclic Sulfonamides with a Bridgehead Nitrogen Atom

“…For many years, sulfonamide‐derived drugs were dramatically prevailed by aromatic derivatives , . However, the recently increased interest to synthesis of their aliphatic counterparts provides an access to yet underexplored parts of pharmaceutically relevant chemical space . Although biologically active five‐ and six‐membered alicyclic sulfonamides were reported in hundreds of papers and patents, their polycyclic analogues remain scarce in the literature (Figure , A ).…”

Chromatographic approach to study the configurational stability of Ni(II) complexes of amino‐acid Schiff bases possessing stereogenic nitrogen

“…Nowadays, the use of tailor‐made AAs in the design of peptides/peptidomimetics with restricted number of conformations and precise positioning of the side chains in the χ‐space is a well‐established paradigm in the design of modern pharmaceuticals . Consequently, the current interest in chemistry of tailor‐made AAs and their analogs, in particular fluorine‐containing, sulfonic, and phosphonic derivatives, is at an all‐time high, exploring new structural ideas, functions, and bio‐properties. Consistent with our long‐standing interest in asymmetric synthesis of tailor‐made AAs and their nonlinear chiroptical properties, such as self‐disproportionation of enantiomers, we were actively contributing to the development of the Ni(II) complex chemistry of AA Schiff bases as a generalized methodology for preparation of various types of tailor‐made AAs (Scheme ) …”