Amino-Modified Polylactic Acid Nanofibre Microspheres as Drug Sustained Release Carriers for Alendronate

Chen, Shunyu; Luo, Zhihan; Wu, Linzhao; Xie, Chunling; Xiao, Xiufeng

doi:10.1080/03602559.2018.1447122

Cited by 10 publications

(6 citation statements)

References 32 publications

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“…The broad absorption band centered at 1100 cm −1 (metal—O—P stretching vibration, blue arrow) and disappeared peak centered at 1235 cm −1 (P=O stretching vibration, black arrow) in Fourier transform infrared (FTIR) spectra confirmed the covalent binding of metal ions to phosphate (Figure 1J ). [ 21 , 22 ] The positive zeta potentials (19.1 ± 0.83 mV for CaALN, 12.06 ± 0.10 mV for MnALN, and 24 ± 1.38 mV for FeALN) could be attributed to the amino group in alendronate, which further verified the successful coordination of alendronate and metal ions. Figure 1G–I showed the pH‐triggered degradation behaviors of CaALN and MnALN, while the degradation rate of FeALN was less than 5% at both pH 7.0 and 5.0 (Figure 1K–M ).…”

Section: Resultsmentioning

confidence: 67%

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Engineering Alendronate‐Composed Iron Nanochelator for Efficient Peritoneal Carcinomatosis Treatment

et al. 2022

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Iron is an essential element for various cellular metabolism. Cancer cells also have high requirement of iron in their proliferation, invasion, and metastasis processes. Alendronate (ALN), a kind of FDA-approved bisphosphonates with metal-chelating capability, is initially certified to selectively bind to intracellular Fe 3+ theoretically and experimentally in this study. Hence, CaALN iron nanochelator is rationally designed to kill cancer cells by synergism of Fe-depletion and calcium accumulation. In vitro experiments and RNA sequencing analysis indicate that CaALN nanomedicine inhibits the proliferation of cancer cells by depleting Fe, interfering with DNA replication, and triggering intracellular reactive oxygen species (ROS). Meanwhile, released Ca 2+ and ROS mutually promote and induce damage of cellular macromolecules, which leads to mitochondrial apoptosis of cancer cells. In an intraperitoneal disseminated mouse model with the human ovarian cancer cells SKOV3, CaALN nanoparticles selectively accumulate in tumor tissues and result in significant retardation of tumor growth and ascites formation. The mean survival time of SKOV3-bearing mice in treatment group is prolonged from 33 to 90 d. These results indicate that the alendronate-originated iron chelator can serve as an efficient strategy for the treatment of peritoneal carcinomatosis.

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Section: Resultsmentioning

confidence: 67%

“…Alendronate, a clinically approved drug for the treatment of osteolytic metastases, [ 21 ] has been reported to have high efficiency in binding with metal ions. However, the interference of alendronate on intracellular ions metabolism was rarely investigated.…”

Section: Resultsmentioning

confidence: 99%

Engineering Alendronate‐Composed Iron Nanochelator for Efficient Peritoneal Carcinomatosis Treatment

et al. 2022

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“…In addition, the sharp peaks at 1640 cm –1 are attributed to the CO bonds. The absorption peaks at 1128 cm –1 are attributed to the characteristic absorption bands of PO in NaAL. , Furthermore, P–O bending vibrations were identified at 469 cm –1 . These findings suggest a successful loading of NaAL.…”

Section: Resultsmentioning

confidence: 71%

Polydopamine-Modified Titanium Dioxide Nanotube Arrays Doped with Calcium as a Sustained Drug Delivery System

Wu,

et al. 2024

ACS Omega

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Titanium nanotube (TNT) arrays manufactured via electrochemical anodization have been widely used as local drug carriers due to their excellent biocompatibility and customizable nanotubular structures. However, the uncontrollable and abrupt drug release at the early stage decreases the drug release duration, leading to excessive drug concentration at the implantation site. In this study, a continuous drug delivery system based on TNTs was created. Initially, a basic ultrasound-assisted approach was utilized to deposit a polydopamine (PDA) coating onto TNTs to obtain PDA-modified TNTs. Next, TNTs-PDA were submerged in a calcium chloride solution to include Ca 2+ through Ca 2+ coordination between the PDA layer's catechol groups. Sodium alendronate (NaAL) was used as a model drug and loaded onto TNTs-PDA-Ca 2+ by immersing them in an NaAL solution. In the final step, NaAL was covalently attached to TNTs-PDA-Ca 2+ through coordination bonds with Ca 2+ . The samples underwent characterization through the use of various techniques, including field emission scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray diffraction patterning, X-ray photoelectron spectroscopy, and inductively coupled plasma emission spectrometry. The results indicated that the bioactivity of TNTs improved, and there was an enhancement in drug loading capacity and release performance due to modification with PDA and Ca 2+ . Furthermore, acidic conditions can cause significant drug release due to the cleavage of coordination bonds between the drug and Ca 2+ ions. Thus, the aforementioned drug delivery system represents a potentially promising approach for achieving sustained and controllable drug release.

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“…Microencapsulation of chemicals in biodegradable polymer carriers is a promising technique because it is more sustainable than non‐biodegradable polymers and also prevents volatilization, degradation and leaching of the chemical while delivering controlled release (Jyothi et al., 2010). Polylactic acid (PLA) and gelatin are the most promising biodegradable coating materials for encapsulation of pesticides; they are environmentally friendly, low cost and easy to scale‐up (Chen et al., 2018). Using these polymers to make pesticide/ attractant microcapsules is a rational choice, and we selected them for use in this study.…”

Section: Introductionmentioning

confidence: 99%

Optimized composite microspheres containing insecticide and attractant for control of Rhagoletis batava obseuriosa Kol. (Diptera: Tephritidae)

Cheng

Sun

et al. 2021

J Applied Entomology

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Ammonium carbonate is used as an attractant for many fruit flies since it releases ammonia in humid atmospheres, which is attractive to them. For integrated pest management in the field, and as part of an 'attract-and-kill' strategy, it is necessary to prolong the release period of ammonia from the ammonium carbonate and combine it with an insecticide. To achieve this, we combined ammonium carbonate with spinosad in slow-release microspheres. The microspheres were prepared using gelatin and polylactic acid as capsule materials. An orthogonal test was used to optimize the parameters needed for production. Particles produced using the optimal parameters were uniform in size (55.5 μm diameter), the spinosad encapsulation rate was 98.1%, the encapsulation concentration of ammonium carbonate was 2.6 mg/g, and they had a longer release period than when the components were not encapsulated. In a field experiment, rates of damage to sea buckthorn by Rhagoletis batava obseuriosa Kol. (Diptera, Tephritidae) (RBO) were 16.05 ± 1.15% in the treatment subplots compared with 81.75 ± 1.50% in the control subplot; the mean number of RBO trapped per trap per day was 21.2 ± 6.3 (SE) in the treatment subplots and 130.8 ± 27.5 (SE) in the control subplot, respectively. Therefore, using composite microspheres has potential as an effective method for control of RBO.

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Amino-Modified Polylactic Acid Nanofibre Microspheres as Drug Sustained Release Carriers for Alendronate

Cited by 10 publications

References 32 publications

Engineering Alendronate‐Composed Iron Nanochelator for Efficient Peritoneal Carcinomatosis Treatment

Engineering Alendronate‐Composed Iron Nanochelator for Efficient Peritoneal Carcinomatosis Treatment

Polydopamine-Modified Titanium Dioxide Nanotube Arrays Doped with Calcium as a Sustained Drug Delivery System

Optimized composite microspheres containing insecticide and attractant for control of Rhagoletis batava obseuriosa Kol. (Diptera: Tephritidae)

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