Amino-decorated mesoporous silica nanoparticles for controlled sofosbuvir delivery

Mehmood, Yasir; Khan, Ikram Ullah; Shahzad, Yasser; Khan, Rizwan Ullah; Khalid, Syed Haroon; Yousaf, Abid Mehmood; Hussain, Talib; Asghar, Sajid; Khalid, Ikrima; Asif, Muhammad; Shah, Supriya

doi:10.1016/j.ejps.2019.105184

Cited by 36 publications

(37 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In both patterns, a broad peak has appeared in an angular (2θ) range of 12−31°, which is attributed to the amorphous network of MSNPs. 75 As is seen in the pattern of the CFM@SiO 2 particles (orange line), another shoulder has emerged at ca. 36−46°that is likely from CFM loaded into the pores and possible interactions between its functional groups with the silanol groups.…”

Section: Resultsmentioning

confidence: 81%

Cefixime-Containing Silica Nanoseeds Coated by a Hybrid PVA-Gold Network with a Cys–Arg Dipeptide Conjugation: Enhanced Antimicrobial and Drug Release Properties

et al. 2021

View full text Add to dashboard Cite

Therapeutic nano-bioconjugates (TNBCs) as an advanced class of drug delivery systems have attracted much attention due to more efficacy than the individual medications. Hence, in this study, a novel anti-infection TNBC system is designed based on highly porous silica nanoparticles, gold nanoparticles (AuNPs), and hybridized polyvinyl alcohol (PVA) for the efficient delivery of cefixime (CFM). Furthermore, a conjugation of cysteine−arginine (CR) dipeptide is made onto the surfaces for the enhancement of cell adhesion. Concisely, the AuNPs incorporated inside the PVA network play the key role in the controlled release process triggered by localized surface plasmon resonance (LSPR) heating. The drug content of the CFM-containing cargo (named as CFM@SiO 2 /PVA/Au−CR) and related release profile have been precisely studied by the confirmed analytical methods. Eventually, confocal microscopy on the stained cells has revealed that the TNBC particles are capable of entering the Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) bacterial cells better than the individual CFM. Also, optical density experiments (OD 600 ) have corroborated that the prepared CFM@SiO 2 /PVA/Au−CR TNBC includes a high antimicrobial effect on K. pneumoniae and E. coli cells with (93.0 ± 1.5) % and (86.8 ± 1.0) % success rates, respectively, whereas the same dosage of the individual CFM has shown a lower effect on the cell growth rate. Also, estimation of minimum inhibitory/ bactericidal concentrations (MIC/MBC) confirmed the enhanced antibacterial property of the CFM through the presented delivery method. Overall, this product is suggested to be clinically administrated instead of the individual CFM due to its high efficacy and containing lower dosage of the antibiotic drug.

show abstract

Section: Resultsmentioning

confidence: 81%

Cefixime-Containing Silica Nanoseeds Coated by a Hybrid PVA-Gold Network with a Cys–Arg Dipeptide Conjugation: Enhanced Antimicrobial and Drug Release Properties

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The silica carrier exhibited a better dissolution profile with >70% cumulative dissolution, compared to the carbon carrier indicating better compatibility between the drug and carrier with little to no interaction resulting in more efficient drug release. Mehmood et al (2020) had researched the oral delivery of a hepatitis C virus inhibitor called sofosbuvir for sustained-release formulation in order to improve its bioavailability. Mesoporous silica nanoparticles were subjected to amino-functionalization using 3-aminopropyl triethoxysilane (APTES) and proceeded with drug loading.…”

Section: Improvement In Solubility and Permeabilitymentioning

confidence: 99%

“… Mehmood et al (2020) had researched the oral delivery of a hepatitis C virus inhibitor called sofosbuvir for sustained-release formulation in order to improve its bioavailability. Mesoporous silica nanoparticles were subjected to amino-functionalization using 3-aminopropyl triethoxysilane (APTES) and proceeded with drug loading.…”

Section: Mesoporous Silica As the Next-generation Drug Delivery Systemmentioning

confidence: 99%

Biocompatible Supramolecular Mesoporous Silica Nanoparticles as the Next-Generation Drug Delivery System

Mohamed

Oo²,

Chatterjee³

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Supramolecular mesoporous silica nanoparticles (MSNs) offer distinct properties as opposed to micron-sized silica particles in terms of their crystal structure, morphology–porosity, toxicity, biological effects, and others. MSN biocompatibility has touched the pharmaceutical realm to exploit its robust synthesis pathway for delivery of various therapeutic molecules including macromolecules and small-molecule drugs. This article provides a brief review of MSN history followed by special emphasis on the influencing factors affecting morphology–porosity characteristics. Its applications as the next-generation drug delivery system (NGDDS) particularly in a controlled release dosage form via an oral drug delivery system are also presented and shall be highlighted as oral delivery is the most convenient route of drug administration with the economical cost of development through to scale-up for clinical trials and market launch.

show abstract

“…Mehmood et al synthesized mesoporous silica using a modified sol-gel method and then functionalized its surface with amino group (Figure 4A). 49 The mesoporous silica nanoparticles loaded with sofosbuvir were surface-modified by a post-synthesis method using 3-aminopropyltriethoxysilane (APTES) and polyvinyl alcohol (PVA) for amino group modification of MSN to realize sustained drug release. The experimental results showed that the amino-decorated MSNs exhibited Fickian diffusion controlled drug release as compared with non-functionalized and PVAgrafted MSNs.…”

Section: Surface Modification and Functionalization Of Mesoporous Silicamentioning

confidence: 99%

The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis

Sha¹,

Dai²,

Song³

et al. 2021

IJN

View full text Add to dashboard Cite

Atherosclerosis (AS) as the leading cause of cardiovascular and cerebrovascular events has been paid much attention all the time. With the continuous development of modern medical drug treatment, surgical treatment, interventional treatment and other methods, the mortality rate of AS has shown a downward trend, while the morbidity rate is still increasing. Oral lipid-lowering or anti-inflammatory drugs are generally used for early AS, but the relatively low accumulation efficiency in lesions and the unavoidable side effects required researchers to develop more effective drug delivery approaches for the therapy of AS. Mesoporous silica nanoparticles as nanocarrier for drug delivery have received extensive attentions due to their flexible size, high specific surface area, controlled pore volume, high drug loading capacity and excellent biocompatibility. Series of good reviews about the mesoporous silica nanoparticles loaded drugs for cancer therapy have been well documented. However, their roles as nanocarrier for drug delivery to treat AS have few reports. In this review, the applications and challenges of mesoporous silica nanomaterials in the field of the diagnosis and therapy of AS have been summarized. The classification, synthesis, formation mechanism, surface modification and functionalization of mesoporous silica nanomaterials which were closely related to the theranostic effect of AS have also been included. Last but not the least, the future prospects’ suggestions of mesoporous silica nanomaterial-based drug delivery system for AS are also provided.

show abstract

Amino-decorated mesoporous silica nanoparticles for controlled sofosbuvir delivery

Cited by 36 publications

References 34 publications

Cefixime-Containing Silica Nanoseeds Coated by a Hybrid PVA-Gold Network with a Cys–Arg Dipeptide Conjugation: Enhanced Antimicrobial and Drug Release Properties

Cefixime-Containing Silica Nanoseeds Coated by a Hybrid PVA-Gold Network with a Cys–Arg Dipeptide Conjugation: Enhanced Antimicrobial and Drug Release Properties

Biocompatible Supramolecular Mesoporous Silica Nanoparticles as the Next-Generation Drug Delivery System

The Opportunities and Challenges of Silica Nanomaterial for Atherosclerosis

Contact Info

Product

Resources

About