Amino-BODIPY as the ratiometric fluorescent sensor for monitoring drug release or “power supply” selector for molecular electronics

Abstract

Amino-BODIPY as the universal and highly fluorescent OFF–ON and ratiometric sensor for thiol-mediated drug release monitoring.

Cytotoxicity of Amino‐BODIPY Modulated via Conjugation with 2‐Phenyl‐3‐Hydroxy‐4(1H)‐Quinolinones

“…Contrary, conjugates 11–15 contain the disulfide linker sensitive to GSH cleavage followed by drug/dye liberation as described previously. [30] …”

“…The synthetic approach to compounds 1–5 and 11–15 was inspired by the described procedure [30] (for details, see Experimental part). The conjugates 6–10 were prepared according to the following Scheme 1 .…”

Fluorescent Reporters for Drug Delivery Monitoring

“…A more general approach for the ratiometric DD monitoring was realized using the dual fluorescent amino‐BODIPY dye (Figure ) . 2‐Phenyl‐3‐hydroxy‐4(1 H )‐quinolinone derivatives, known for their anticancer activity, were utilized as the model drugs.…”

A Chromone‐Based Fluorescent Chemosensor for Detecting Cu2+

“…Chromone derivatives are widely used as fluorophores in chemosensor field together with anthracene, rhodamine, BODIPY, and coumarin. [17][18][19][20][21][22][23][24][25][26] In addition to its role as a fluorophore, chromone-based compounds are well applied in biomedical fields such as antitumoral agents and cardiocerebrovascular drugs due to their outstanding spectroscopic and pharmacological properties. [27][28][29] Nevertheless, chemosensors having the chromone moiety have not been used for the practical application such as paper strip.…”

“…Chromone derivatives are widely used as fluorophores in chemosensor field together with anthracene, rhodamine, BODIPY, and coumarin . In addition to its role as a fluorophore, chromone‐based compounds are well applied in biomedical fields such as antitumoral agents and cardio‐cerebrovascular drugs due to their outstanding spectroscopic and pharmacological properties .…”