Amino Acyl Conjugates of Nitrogen Heterocycles as Potential Pharmacophores

Katritzky, Alan R.; Bajaj, Kiran; Charpentier, Maël; Zadeh, Ebrahim H. Ghazvini

doi:10.1021/jo100625y

Cited by 7 publications

(3 citation statements)

References 31 publications

(44 reference statements)

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“…Lithiated substrates 2-methylpyridine, 4-methylpyridine, and 2-methylquinoline reacted with N -(Cbz-α-aminoacyl)benzotriazoles 126 and afforded N -(α-Cbz-aminoacyl)methylene heterocycles 127 , 128 , and 129 , respectively (Scheme 47 ). 58…”

Section: Applications Of N -Acylbenzotriazoles In Org...mentioning

confidence: 99%

“…Lithiated substrates 2-methylpyridine, 4-methylpyridine, and 2-methylquinoline reacted with N-(Cbz--aminoacyl)benzotriazoles 126 and afforded N-(-Cbz-aminoacyl)methylene heterocycles 127, 128, and 129, respectively (Scheme 47). 58 C-Acylations have been widely considered as a valuable technique in C-C bond formation and therefore are synthetically important. [59][60][61] Carbon acylation of simple ketone enolates has been explored for the synthesis of 1,3-keto esters and 1,3-diketones using different acylating reagents such as acid chlorides, 62 acyl cyanides, 63,64 N-acylimidazoles, 65 methyl methoxymagnesium carbonate, 66 formates, and oxalates.…”

Section: Review Synopenmentioning

confidence: 99%

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Synthetic Utility of N-Acylbenzotriazoles

Tiwari,

Yadav,

Gupta

et al. 2023

SynOpen

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N-Acylbenzotriazoles are valuable synthons in organic synthesis. They are particularly used as acylating agents and an alternative to acyl chloride. They have been widely explored for a diverse range of applications. This review summarizes the methods for the preparation of N-acylbenzotriazole derivatives and their diverse applications in particular demonstration to serve as alternative acylating agents in organic transformations such as N-, O-, C-, and S-acylating agents for the convenient synthesis of a wide range of biologically important organic compounds. We also emphasize the synthesis of diverse compounds using benzotriazole ring cleavage (BtRC) methodology, including its pharmacophore study and some notable utilities as valuable starting materials, ligands, and intermediates in the field of organic synthesis.

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Section: Applications Of N -Acylbenzotriazoles In Org...mentioning

confidence: 99%

Section: Review Synopenmentioning

confidence: 99%

Synthetic Utility of N-Acylbenzotriazoles

Tiwari,

Yadav,

Gupta

et al. 2023

SynOpen

View full text Add to dashboard Cite

show abstract

“…Nitrogen-containing heterocycles have attracted much attention in the organic and medicinal chemistry fields for their diverse biological properties and pharmacophores [1][2][3][4]. Quinoline derivatives are a very important class of nitrogen-containing heterocycles, which display a broad range of biological activities such as antibacterial, antimalaria, anti-asthmatic, antitumor, antiplatelet, etc.…”

Section: Introductionmentioning

confidence: 99%