Amino-Aciduria in Salicylate Intoxication

Proximal Tubule Dysfunction Secondary to Salicylate Intoxication

“…In conclusion, our case report further substantiates the possibility of transient Fanconi-like syndrome following salicylate overdose, as previously documented. 6-10 These findings highlight the need for serial urinalyzes to monitor for proximal tubule dysfunction, even after clinical correction of salicylate toxicity, and to ensure resolution of the proximal tubule dysfunction if present.…”

“…17 It appears that once the salicylate is cleared from the body, proximal tubule epithelial cells return to baseline function and the glucosuria and proteinuria that can develop with toxic levels of ASA are transient and resolve within 2 weeks in all of the cases of proximal tubule dysfunction described in children to date, including in our patient. 6-10…”

The 2010 Nephrology Quiz and Questionnaire

“…In addition to ibuprofen, aspirin overdose has also been associated with reversible proximal tubule dysfunction (12,13). In one case a 17-year-old girl took 25 tablets of aspirin (12.5 g acetylsalicylic acid) and 12 hours later was noted to have generalized proximal tubular dysfunction with normoglycemia, glycosuria, aminoaciduria, uricosuria, and normal gap metabolic acidosis.…”

“…In the VICTOR trial, there was equal development of resistance in the intravenous ganciclovir and oral ganciclovir groups at 1 year (13). Recent guidelines suggest that resistance should be considered and immunosuppression reduced, only after 2 weeks of adequate dosing with an unchanged or increasing viral load (14).…”

Sweat Chloride Concentration

“…19 The number of cases reviewed in this communication is large enough to warrant a precise conclusion regarding the re¬ sults. Thirty males and 25 females comprised the group.…”