Amino Acids and Their Biological Derivatives Modulate Protein–Protein Interactions in an Additive Way
Xufeng Xu,
Francesco Stellacci
Abstract:Protein−protein interactions (PPIs) differ when measured in test tubes and cells due to the complexity of the intracellular environment. Free amino acids (AAs) and their derivatives constitute a significant fraction of the intracellular volume and mass. Recently, we have found that AAs have a generic property of rendering protein dispersions more stable by reducing the net attractive part of PPIs. Here, we study the effects on PPIs of different AA derivatives, AA mixtures, and short peptides. We find that all … Show more
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