Amino acid transport by the small intestine of the rat

Munck, B. G.

doi:10.1016/0926-6585(65)90017-8

Cited by 48 publications

(36 citation statements)

References 21 publications

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“…In human fibroblasts, there appears to exist two distinct systems similar to the L system (15). Glycine has been shown to be transported by a variety of systems (18,19,20). Different mechanisms of glycine uptake exist in various mammalian tissues, e.g., two systems in ascites cells (21) and an irninoglycine system in renal tubules (1 1).…”

Section: Speculationmentioning

confidence: 99%

Glycine Transport by Human Diploid Fibroblasts—Absence of a Defect in Cells from Patients with Nonketotic Hyperglycinemia

1979

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Section: Speculationmentioning

confidence: 99%

Glycine Transport by Human Diploid Fibroblasts—Absence of a Defect in Cells from Patients with Nonketotic Hyperglycinemia

1979

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“…in their diet is directly exposed to high concentrations of this substance, that its inhibitory action upon aminoacid transport may be more profound than after subcutaneous administration. Munck (1965) has shown that 4-deoxypyridoxine equally inhibits hydroxyproline, arginine, and threonine transport through the gut wall. Since these are the three known amino-acid transport systems through the intestinal wall, it is probable, a priori, that isoniazid in such high doses would have a marked effect upon aminoacid absorption.…”

mentioning

confidence: 99%

On the pattern of change in peripheral nerves produced by isoniazid intoxication in rats

Cavanagh¹

1967

Journal of Neurology, Neurosurgery & Psychiatry

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“…Threonine released during enzymatic digestion is rapidly absorbed via different sodium-dependent and -independent transport systems in the brush border membrane of the small intestine (Munck and Munck, 1994;Massey et al, 1998). In pigs, the apparent ileal digestibility of threonine in feed ingredients varies: about 63 % for cottonseed and linseed meal, 59-72 % for cereals and 77-90 % for soybean meal/soy isolate, milk/whey and fish meals (NRC, 1998).…”

Section: Conclusion and Recommendationsmentioning

confidence: 99%

Scientific opinion on the safety and efficacy of L‐threonine produced by Escherichia coli (FERM BP‐10942) for all animal species based on a dossier submitted by Ajinomoto Eurolysine SAS

Feed¹

2013

EFS2

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The product L-threonine, technically pure, is an essential amino acid that contains by specification ≥ 98 % Lthreonine. It is produced by a genetically modified Escherichia coli strain. Neither the production strain nor its recombinant DNA was detectable in the final product. The final product does not raise safety concerns with regard to the genetic modification. L-Threonine, technically pure, is considered safe for the target animals when used to meet the requirements. The toxicological studies, including mutagenicity tests, performed with the additive or other sources of L-threonine did not reveal any toxic effect. Since the composition of tissues and products of animal origin will not be changed by the use of L-threonine in animal nutrition, and considering the high purity of the product under assessment, no risks are expected for the consumer from the use of L-threonine, technically pure, as a feed additive. The product is not irritating to the skin or eyes and is not likely to be a skin sensitiser. Although there is a potential for user exposure by inhalation, there is no evidence of acute toxicity by the inhalation route. The use of the product as a feed additive does not represent a risk to the environment. LThreonine, technically pure, is considered as an efficacious source of L-threonine for all animal species. Response in ruminants requires some degree of protection of threonine from ruminal degradation. SUMMARYFollowing a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of the product L-threonine, technically pure, for all animal species.Threonine is an essential amino acid, considered as the second limiting amino acid in pig feed and probably as the third limiting in poultry feed. Supplementing feedingstuffs with free threonine would ensure that the animal requirements for that amino acid are met.The product L-threonine, technically pure, contains by specification ≥ 98 % L-threonine. It is produced by a genetically modified Escherichia coli strain.Neither the production strain nor its recombinant DNA was detectable in the final product. The final product does not raise safety concerns with regard to the genetic modification.L-Threonine, technically pure, is considered safe for the target animals when used to meet the requirements.The toxicological studies, including mutagenicity tests, performed with the additive or other sources of L-threonine did not reveal any toxic effect. Since the composition of tissues and products of animal origin will not be changed by the use of L-threonine in animal nutrition, and considering the high purity of the product under assessment, no risks are expected for the consumer from the use of Lthreonine, technically pure, as a feed additive.The product is not irritating to the skin or eyes and is not likely to be a skin sensitiser. Although there is a potential for user exposure by inhalation, there is no evidence of acute tox...

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Amino acid transport by the small intestine of the rat

Cited by 48 publications

References 21 publications

Glycine Transport by Human Diploid Fibroblasts—Absence of a Defect in Cells from Patients with Nonketotic Hyperglycinemia

Glycine Transport by Human Diploid Fibroblasts—Absence of a Defect in Cells from Patients with Nonketotic Hyperglycinemia

On the pattern of change in peripheral nerves produced by isoniazid intoxication in rats

Scientific opinion on the safety and efficacy of L‐threonine produced by Escherichia coli (FERM BP‐10942) for all animal species based on a dossier submitted by Ajinomoto Eurolysine SAS

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