Amino acid substitutions in genetic variants of human serum albumin and in sequences inferred from molecular cloning.

Takahashi, Nobuhiro; Takahashi, Yōko; Blumberg, Baruch S.; Putnam, Frank W.

doi:10.1073/pnas.84.13.4413

Cited by 44 publications

(50 citation statements)

References 31 publications

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“…In the present work the five variants were compared at pH 4.0 and 5.6 with reference alloalbumins for which the substitution was known. The reference variants with known substitutions are albumin Mexico (slow + 1, 550 Asp Gly) (10), albumin B Lubeck (slow +2, 570 Glu -* Lys) (15), and proalbumin Pollibauer (Lille type, slow +2, -2 Arg -+ His) (11). The five Japanese variants showed different combinations of mobilities in the two buffer systems; all were also different from albumin B and proallbumin Pollibauer.…”

Section: Resultsmentioning

confidence: 99%

“…For want of structural information such variants generally have been assigned ethnic or geographical names. Recently we (4,(9)(10)(11)(12)(13)(14)(15) and others (16)(17)(18)(19)(20)(21) have determined the structural change in a number of variant albumins. We have now completed the structural study of the five rare types of inherited albumin variants discovered in the Biochemical Genetics Study of the Radiation Effects Research Foundation (RERF); this surveyed some 30 blood and plasma polypeptides in a cohort of 15,581 unrelated children in Nagasaki and Hiroshima (2).…”

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confidence: 99%

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Point substitutions in Japanese alloalbumins.

Arai

Madison²,

Huss³

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

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We have completed the structural study of five rare types of inherited albumin variants (alloalbumins) discovered in the Biochemical Genetics Study of 15,581 unrelated children in Hiroshima and Nagasaki. We have also identified the structural chane inl five other alloalbumin specimens detected during clinical electrophoresis of sera from Japanese living near Tokyo. Each of the five albumin variants from Nagasaki and Hiroshima has a single amino acid substitution. AlU of these substitutions differ, and none has been reported in non-Japanese populations. No instances of proalbumin variants or of albumin B (the most frequent alloalbumins in Caucasians) were detected in the children in Hiroshima and Nagasaki. However, one instance of a variant proalbumin and two examples of albumin B occurred in Japanese from the vicinity of Tokyo. In addition a previously unreported point substitution was found in albumin Tochigi, which is present in two unrelated persons from Tochigi prefecture. Four of the point mutations in the Japanese alloalbumins are in close proximity in a short segment of the polypeptide chain (residues 354-382) in which three additional point substitutions have been reported in diverse populations. These results, combined with earlier data, suggest that point substitutions are grouped in certain segments of the albumin molecule.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Point substitutions in Japanese alloalbumins.

Arai

Madison²,

Huss³

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

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“…All individuals were heterozygous for the trait except for one homozygous Naskapi donor (12,13). Purification of the albumin from serum samples was described by Takahashi et al (12).…”

Section: Methodsmentioning

confidence: 99%

“…Previously described methods used for the characterization of the albumin variants and for structural study include the following: (i) NaDodSO4/PAGE of the carboxymethylated albumins and CNBr digests (13), (it) automated tandem HPLC mapping of tryptic peptides (12), (iii) HPLC mapping and isoelectric focusing of CNBr peptides (13), and (iv) amino acid-sequence analysis of the intact purified albumin and of tryptic and CNBr peptides with the Beckman sequencer model 890C (12), radioautography with 63Ni2+ (8). RESULTS tTo whom reprint requests should be addressed.…”

Section: Methodsmentioning

confidence: 99%

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Structural changes and metal binding by proalbumins and other amino-terminal genetic variants of human serum albumin.

Takahashi

Putnam

1987

Proc. Natl. Acad. Sci. U.S.A.

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Proalbumins are rare genetic variants of human serum albumin containing a basic propeptide that is not removed during post-transcriptional processing because of a mutation in the site of excision, an Arg-Arg sequence. We have identified the amino acid substitutions in three different types of proalbumins designated Gainesville, Taipei, and Takefu. The first two proalbumins are identical to previously described proalbumins of the Christchurch and Lille types, respectively, and exhibit the characteristic properties ofsusceptibility to tryptic cleavage and of lower metal-binding affinity. Takefu is a third

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Implications of the distribution of Albumin Naskapi and Albumin Mexico for new world prehistory

Smith

Lorenz

Rolfs

et al. 2000

Am. J. Phys. Anthropol.

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The known distributions of two mutational variants of the albumin gene that are restricted to Mexico and/or North America, Albumin Mexico (AL*Mexico) and Albumin Naskapi (AL*Naskapi), were expanded by the electrophoretic analysis of sera collected from more than 3,500 Native Americans representing several dozen tribal groups. With a few exceptions that could be due to recent, isolated cases of admixture, AL*Naskapi is limited to groups that speak Athapaskan and Algonquian, two widely distributed language families not thought to be related, and to several linguistically unrelated groups geographically proximate to its probable ancestral homeland. Similarly, AL*Mexico is limited to groups that speak Yuman or Uto-Aztecan, two language groups in the American Southwest and Baja California not thought to be closely related to each other, and to several linguistically unrelated groups throughout Mexico. The simultaneous consideration of genetic, historical, linguistic, and archaeological evidence suggests that AL*Naskapi probably originated on the northwestern coast of North America, perhaps in some group ancestral to both Athapaskans and Algonquians, and then spread by migration and admixture to contiguous unrelated, or distantly related, tribal groups. AL*Mexico probably originated in Mexico before 3,000 years BP then spread northward along the Tepiman corridor together with cultural influences to several unrelated groups that participated in the Hohokam culture. Am

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Amino acid substitutions in genetic variants of human serum albumin and in sequences inferred from molecular cloning.

Abstract: The structural changes in four genetic variants of human serum albumin were analyzed by tandem high-pressure liquid chromatography (HPLC) of the tryptic peptides, HPLC mapping and isoelectric focusing of the CNBr

Cited by 44 publications

References 31 publications

Point substitutions in Japanese alloalbumins.

Point substitutions in Japanese alloalbumins.

Structural changes and metal binding by proalbumins and other amino-terminal genetic variants of human serum albumin.

Implications of the distribution of Albumin Naskapi and Albumin Mexico for new world prehistory

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