Amino acid profiles in the tissue and serum of patients with liver cancer

Abstract

Most patients with liver cancer were found late and lost the chance of surgery. Liquid biopsy can monitor the risk of tumor recurrence and metastasis, quickly evaluate the curative effect of tumor treatment, and is conducive to early screening and auxiliary diagnosis of high-risk groups. Amino acid (AA) profiling has been used to the diagnosis and the prognosis for cancers. However, little was known about the profiles of AA of liver cancer. In this study, we used tRNA in Cancer database to analyze the AA levels in liver cancer tissues. Blood samples of patients with liver cancer were collected and analyzed using the automatic AA analyzer. We found that valine, isoleucine, and leucine were decreased significantly both in the plasma and the tumor tissues of patients with liver cancer. However, upregulation of methionine was observed in tissues and plasma of patients with liver cancer. Interestingly, tyrosine, and phenylalanine were decreased in tumor tissue but increased in the plasma of patients with liver cancer. This is the first report provided an overview of AA profile in both plasma and tissue for patients with liver cancer. AA levels can be used as diagnostic and prognostic markers of patients with liver cancer.

Effect of secretory DKK3 on circulating CD56bright natural killer cells in patients with liver cancer

“…The details can be found in our previous study. 18 All patients provided informed consent. This study was conducted according to the Helsinki Declaration of 1975 and approved by the Ethics Committee of Liaoning Medical University (20170013).…”

Systematic Metabolic Profiling of Mice with Sleep‐Deprivation

“…[50][51][52] Reduced levels of tyrosine and phenylalanine in tumor tissue from liver cancer patients can be used as markers for early diagnosis. [53] Tryptophan is an essential amino acid that is a precursor to melatonin. The pineal gland produces melatonin, regulates sleep and wakefulness, plays a role in satiety-induced drowsiness, and can be a dietary supplement to improve sleep, [54][55][56][57] and treat microbial infections.…”

The Role of Amino Acids in Non-Enzymatic Antioxidant Mechanisms in Cancer: A Review

“…Thus, in their study, Cao et al demonstrated a high content of the amino acids Phe and Tyr in viable tumor areas of non-small cell lung cancer [ 154 ]. Another study found an increase in serum Phe and Tyr in hepatocellular cancer (HCC) [ 155 ]. It is noteworthy that there are practically no data on the biochemical processes and reasons for the increase in this amino acid in oncological conditions, and on its role in redox homeostasis.…”