Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies

Calvani, Riccardo; Picca, Anna; Rodríguez‐Mañas, Leocadio; Tosato, Matteo; Coelho-Júnior, Hélio José; Biancolillo, Alessandra; Laosa, Olga; Gervasoni, Jacopo; Primiano, Aniello; Santucci, Lavinia; Giampaoli, Ottavia; Bourdel-Marchasson, I.; Regueme, Sophie; Sinclair, Alan J.; Urbani, Andrea; Landi, Francesco; Gambassi, Giovanni; Marini, Federico; Marzetti, Emanuele

doi:10.3390/metabo13040542

Cited by 5 publications

(1 citation statement)

References 100 publications

(113 reference statements)

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“…Of note, recent studies showed that SR and NMDAR are highly expressed in human pancreatic islet β cells [ 87 ], and systemic D-serine administration modulates insulin secretion in a dose-dependent manner [ 88 , 89 ]. Despite we found similar serum D-serine levels between diabetic and non-diabetic subjects, L-serine and L-glutamate were increased in diabetic compared to non-diabetic group, consistently with previous blood metabolomics evidence [ 16 , 17 ]. In line with other studies [ 90 ], we also observed a positive correlation between serum L-glutamate concentration, BMI and visceral adiposity in both non-frail and frail participants.…”

Section: Discussionsupporting

confidence: 91%

Serum dysregulation of serine and glycine metabolism as predictive biomarker for cognitive decline in frail elderly subjects

Imarisio,

Yahyavi,

Gasparri

et al. 2024

Transl Psychiatry

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Frailty is a common age-related clinical syndrome characterized by a decline in the function of multiple organ systems, increased vulnerability to stressors, and a huge socio-economic burden. Despite recent research efforts, the physiopathological mechanisms underlying frailty remain elusive and biomarkers able to predate its occurrence in the early stages are still lacking. Beyond its physical component, cognitive decline represents a critical domain of frailty associated with higher risk of adverse health outcomes. We measured by High-Performance Liquid Chromatography (HPLC) a pool of serum amino acids including L-glutamate, L-aspartate, glycine, and D-serine, as well as their precursors L-glutamine, L-asparagine, and L-serine in a cohort of elderly subjects encompassing the entire continuum from fitness to frailty. These amino acids are known to orchestrate excitatory and inhibitory neurotransmission, and in turn, to play a key role as intermediates of energy homeostasis and in liver, kidney, muscle, and immune system metabolism. To comprehensively assess frailty, we employed both the Edmonton Frail Scale (EFS), as a practical tool to capture the multidimensionality of frailty, and the frailty phenotype, as a measure of physical function. We found that D-serine and D-/Total serine ratio were independent predictors of EFS but not of physical frailty. Furthermore, higher levels of glycine, glycine/L-serine and D-/Total serine were associated with worse cognition and depressive symptoms in the frail group. These findings suggest that changes in peripheral glycine and serine enantiomers homeostasis may represent a novel biochemical correlate of frailty.

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Section: Discussionsupporting

confidence: 91%

Serum dysregulation of serine and glycine metabolism as predictive biomarker for cognitive decline in frail elderly subjects

Imarisio,

Yahyavi,

Gasparri

et al. 2024

Transl Psychiatry

View full text Add to dashboard Cite

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Biomarkers of frailty

El Assar,

Rodríguez-Sánchez,

Álvarez-Bustos

et al. 2024

Molecular Aspects of Medicine

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Serum D-serine to total serine ratio and glycine levels as predictive biomarkers for cognitive dysfunction in frail elderly subjects

Imarisio,

Yahyavi,

Gasparri

et al. 2024

Preprint

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Frailty is a common age-related clinical syndrome characterized by a decline in the function of multiple organ systems, increased vulnerability to stressors and huge socio-economic burden. Despite recent research efforts, the physiopathological mechanisms concurring to determine frailty remain elusive and biomarkers able to predate its occurrence in the early stages are still lacking. Beyond its physical component, cognitive decline represents a critical domain of frailty associated with higher risk of adverse health outcomes. We measured by High Performance Liquid Chromatography (HPLC) a pool of serum amino acids including L-glutamate, L-aspartate, glycine and D-serine, as well as their precursors L-glutamine, L-asparagine and L-serine in a cohort of elderly subjects encompassing the entire continuum from fitness to frailty. These amino acids are known to orchestrate excitatory and inhibitory neurotransmission, and in turn, to play a key role as intermediates of energy homeostasis and in liver, kidney, muscle and immune system metabolism. To comprehensively assess frailty, we employed both the Edmonton Frail Scale (EFS), as a practical tool to capture the multidimensionality of frailty, and the frailty phenotype, as a measure of physical function. We found that D-serine and D-/Total serine ratio were independent predictors of EFS but not of physical frailty. Furthermore, higher glycine levels and D-/Total serine correlated with worse cognition and depressive symptoms in the frail group. These findings suggest that altered homeostasis of D-serine may represent a biochemical signature of frailty, while increased serum glycine and D-/Total serine ratio could be specifically associated with cognitive decline and depression in frail older populations.

show abstract

Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies

Cited by 5 publications

References 100 publications

Serum dysregulation of serine and glycine metabolism as predictive biomarker for cognitive decline in frail elderly subjects

Serum dysregulation of serine and glycine metabolism as predictive biomarker for cognitive decline in frail elderly subjects

Biomarkers of frailty

Serum D-serine to total serine ratio and glycine levels as predictive biomarkers for cognitive dysfunction in frail elderly subjects

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