Amino acid PET and MR perfusion imaging in brain tumours

Filß, Christian; Cicone, Francesco; Shah, N. Jon; Galldiks, Norbert; Langen, Karl‐Josef

doi:10.1007/s40336-017-0225-z

Cited by 54 publications

(35 citation statements)

References 158 publications

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“…Our particular study design might also explain the lack of significant correlation between MET uptake and rCBV. Overall, we clearly demonstrate that MET PET has advantages over PWI, which is in line with previous studies [49,50], but in contrast to others [51].…”

supporting

confidence: 92%

Region-by-region analysis of PET, MRI, and histology in en bloc-resected oligodendrogliomas reveals intra-tumoral heterogeneity

Roodakker

Alhuseinalkhudhur

Al-Jaff

et al. 2018

Eur J Nucl Med Mol Imaging

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Purpose Oligodendrogliomas are heterogeneous tumors in terms of imaging appearance, and a deeper understanding of the histopathological tumor characteristics in correlation to imaging parameters is needed. We used PET-to-MRI-to-histology coregistration with the aim of studying intra-tumoral 11 C-methionine (MET) uptake in relation to tumor perfusion and the protein expression of histological cell markers in corresponding areas. Methods Consecutive histological sections of four tumors covering the entire en bloc-removed tumor were immunostained with antibodies against IDH1-mutated protein (tumor cells), Ki67 (proliferating cells), and CD34 (blood vessels). Software was developed for anatomical landmarks-based co-registration of subsequent histological images, which were overlaid on corresponding MET PET scans and MRI perfusion maps. Regions of interest (ROIs) on PET were selected throughout the entire tumor volume, covering hot spot areas, areas adjacent to hot spots, and tumor borders with infiltrating zone. Tumor-to-normal tissue (T/ N) ratios of MET uptake and mean relative cerebral blood volume (rCBV) were measured in the ROIs and protein expression of histological cell markers was quantified in corresponding regions. Statistical correlations were calculated between MET uptake, rCBV, and quantified protein expression. Results A total of 84 ROIs were selected in four oligodendrogliomas. A significant correlation (p < 0.05) between MET uptake and tumor cell density was demonstrated in all tumors separately. In two tumors, MET correlated with the density of proliferating cells and vessel cell density. There were no significant correlations between MET uptake and rCBV, and between rCBV and histological cell markers. Conclusions The MET uptake in hot spots, outside hotspots, and in infiltrating tumor edges unanimously reflects tumor cell density. The correlation between MET uptake and vessel density and density of proliferating cells is less stringent in infiltrating tumor edges and is probably more susceptible to artifacts caused by larger blood vessels surrounding the tumor. Although based on a limited number of samples, this study provides histological proof for MET as an indicator of tumor cell density and for the lack of statistically significant correlations between rCBV and histological cell markers in oligodendrogliomas.

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supporting

confidence: 92%

Region-by-region analysis of PET, MRI, and histology in en bloc-resected oligodendrogliomas reveals intra-tumoral heterogeneity

Roodakker

Alhuseinalkhudhur

Al-Jaff

et al. 2018

Eur J Nucl Med Mol Imaging

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“…With regard to tumor uptake, L-amino acid radiotracers in general show remarkable advantages over their corresponding D-isomer due to the preference of amino acid transporters and related enzymes for the L-isomer. As such, most amino acid PET radiotracers currently used in the clinic are L-isomers 39,40 . However, at times, D-amino acid PET radiotracers display a similar tumor uptake as their L-counterparts and in some cases, have superior contrast performance to L-isomers due to their fast clearance from the blood pool [43][44][45] .…”

Section: Discussionmentioning

confidence: 99%

“…It is common that the L-enantiomer of an amino acid PET tracer has higher tumor uptake than its D-counterpart 39,40 . Consistent with this, in breast cancer, it has previously been shown that L-and D-enantiomers of 1-[ 18 F]FETrp have different uptake profiles 33 .…”

Section: Specificity Of the 1-l-[ 18 F]fetrp Uptake In Medulloblastommentioning

confidence: 99%

PET imaging of medulloblastoma with an 18F-labeled tryptophan analogue in a transgenic mouse model

Xin

Yue

et al. 2020

Sci Rep

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In vivo positron emission tomography (pet) imaging is a key modality to evaluate disease status of brain tumors. In recent years, tremendous efforts have been made in developing PET imaging methods for pediatric brain tumors. Carbon-11 labelled tryptophan derivatives are feasible as PET imaging probes in brain tumor patients with activation of the kynurenine pathway, but the short half-life of carbon-11 limits its application. Using a transgenic mouse model for the sonic hedgehog (Shh) subgroup of medulloblastoma, here we evaluated the potential of the newly developed 1-(2-[ 18 F]fluoroethyl)-L-tryptophan (1-L-[ 18 f]fetrp) as a pet imaging probe for this common malignant pediatric brain tumor. 1-L-[ 18 F]FETrp was synthesized on a PETCHEM automatic synthesizer with good chemical and radiochemical purities and enantiomeric excess values. Imaging was performed in tumor-bearing Smo/ Smo medulloblastoma mice with constitutive actvation of the Smoothened (Smo) receptor using a PerkinElmer G4 PET-X-Ray scanner. Medulloblastoma showed significant and specific accumulation of 1-L-[ 18 F]FETrp. 1-L-[ 18 F]FETrp also showed significantly higher tumor uptake than its D-enantiomer, 1-D-[ 18 F]FETrp. The uptake of 1-L-[ 18 F]FETrp in the normal brain tissue was low, suggesting that 1-L-[ 18 f] fetrp may prove a valuable pet imaging probe for the Shh subgroup of medulloblastoma and possibly other pediatric and adult brain tumors.

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“…However, the inherent limitation of high physiologic uptake in the normal brain tissue necessitates the search for other newer PET tracers. Although 13 Nammonia has a short half-life time, it is rapidly spreading in recent years because of its diagnostic power (perfusion-metabolism coupling tracer) and the easier interpretation for clinicians owing to the higher tumor to back-ground contrast compared to PWI and other PET tracers [31] . On the other hand, the short half-life time has the advantage of reducing the radiation.…”

Section: Discussionmentioning

confidence: 99%

Differentiation of suprasellar meningiomas from non-functioning pituitary macroadenomas by 18F-FDG and 13N-Ammonia PET/CT

Ding

Zhang

et al. 2020

Preprint

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Background: Differentiation of suprasellar meningiomas (SSMs) from non-functioning pituitary macroadenomas (NFPMAs) is useful for clinical management. We investigated the utility of 13 Nammonia combined with 18 F-FDG positron emission tomography (PET)/computed tomography (CT) in distinguishing SSMs from NFPMAs retrospectively.Methods: Fourteen NFPMAs patients and eleven SSMs patients with histopathologic diagnosis were included in this study. Every patient underwent both 18 F-FDG and 13 N-ammonia PET/CT scans. The tumor to gray matter (T/G) ratios were calculated for the evaluation of tumor uptake.Results: The uptake of 18 F-FDG was higher in NFPMAs than SSMs, whereas the uptake of 1 3 Nammonia was obviously lower in NFPMAs than SSMs. The differences of 18 F-FDG and 13 N-ammonia uptake between the two groups were significant respectively (0.92[0.46] vs 0.59[0.29], P <0.05, 18 F-FDG; 1.58±0.56 vs 2.80±1.45, P <0.05, 13 N-ammonia). Tumor classification demonstrated a high overall accuracy of 96.0% for differential diagnosis. When the two traces were combined, only 1 SSM was misclassified into the NFPMA group.Conclusion : SSMs and NFPMAs have different metabolic characteristics on 18 F-FDG and 13 Nammonia PET images. The combination of these two tracers can effectively distinguish SSMs from NFPMAs.

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Amino acid PET and MR perfusion imaging in brain tumours

Cited by 54 publications

References 158 publications

Region-by-region analysis of PET, MRI, and histology in en bloc-resected oligodendrogliomas reveals intra-tumoral heterogeneity

Region-by-region analysis of PET, MRI, and histology in en bloc-resected oligodendrogliomas reveals intra-tumoral heterogeneity

PET imaging of medulloblastoma with an 18F-labeled tryptophan analogue in a transgenic mouse model

Differentiation of suprasellar meningiomas from non-functioning pituitary macroadenomas by 18F-FDG and 13N-Ammonia PET/CT

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