Amino Acid Nutrition and Reproductive Performance in Ruminants

Gilbreath, Kyler R; Bazer, Fuller W.; Satterfield, M. Carey; Wu, Guoyao

doi:10.1007/978-3-030-54462-1_4

Cited by 35 publications

(36 citation statements)

References 117 publications

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“…Citrulline is a non-essential amino acid considered a biomarker for enterocyte mass, epithelial cell damage, and absorptive function [ 41 , 42 ]. The administration of citrulline to pregnant ewes and cows improves embryo survival [ 43 ] and tends to increase the number of antral follicles in the ovaries of ewes [ 44 ]. Furthermore, citrulline has several functions: protein synthesis, intestinal homeostasis, nitrogen balance, growth and development, anti-oxidation, muscle performance, intestinal functions, renal function, exercise performance, blood pressure, vasodilation, and anti-inflammatory action [ 45 , 46 , 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

Impacts of Different Prenatal Supplementation Strategies on the Plasma Metabolome of Bulls in the Rearing and Finishing Phase

Polizel¹,

Fernandes²,

Furlan³

et al. 2023

Metabolites

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This study investigated the effects of maternal nutrition on the plasma metabolome of Nellore bulls in the rearing and finishing phases, and metabolic differences between these phases. For this study, three nutritional approaches were used in 126 cows during pregnancy: NP—(control) mineral supplementation; PP—protein-energy supplementation in the final third; and FP—protein-energy supplementation during the entire pregnancy. We collected blood samples from male offspring in the rearing (450 ± 28 days old) and finishing phases (660 ± 28 days old). The blood was processed, and from plasma samples, we performed the targeted metabolome analysis (AbsoluteIDQ® p180 Kit). Multiple linear regression, principal component analysis (PCA), repeated measures analysis over time, and an enrichment analysis were performed. PCA showed an overlap of treatments and time clusters in the analyses. We identified significant metabolites among the treatments (rearing phase = six metabolites; finishing phase = three metabolites) and over time (21 metabolites). No significant metabolic pathways were found in the finishing phase, however, we found significant pathways in the rearing phase (Arginine biosynthesis and Histidine metabolism). Thus, prenatal nutrition impacted on plasma metabolome of bulls during the rearing and finishing phase and the different production stages showed an effect on the metabolic levels of bulls.

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Section: Discussionmentioning

confidence: 99%

Impacts of Different Prenatal Supplementation Strategies on the Plasma Metabolome of Bulls in the Rearing and Finishing Phase

Polizel¹,

Fernandes²,

Furlan³

et al. 2023

Metabolites

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show abstract

“…In addition, it has been reported that SNX5 stimulates autophagy during viral infection [19]. In cattle, amino acids are essential for the survival and development of embryo during early pregnancy periods [20,21]. Moreover, amino acid concentrations in uterine fluids during early pregnancy differ in fertile and subfertile dairy cows [22].…”

Section: Discussionmentioning

confidence: 99%

Characterization of Serum Metabolome and Proteome Profiles Identifies SNX5 Specific for Pregnancy Failure in Holstein Heifers

Kusama

Bai

Matsuno

et al. 2022

Life

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Pregnancy loss predominantly occurs during the first 3–4 weeks due to fertilization failure or early embryonic losses in cattle. Insufficient biochemical communication between conceptus (embryo plus extraembryonic membranes) and endometrium has been suspected as the primary cause for early embryonic losses. If molecules regulating this communication were identified, molecular mechanisms associated with early pregnancy losses could be better understood. To identify candidate molecules as detection markers of non-pregnant or females undergoing embryonic loss, peripheral blood from embryo-transferred heifers on day 7 (day 0 = day of estrus) were collected on days 17 (pre-attachment), 20 (during attachment), and 22 (post-attachment), which were subjected to metabolome and global proteome iTRAQ analyses. The metabolome analysis partly divided serum components into pregnant or not. In the iTRAQ analysis, heatmap analysis with top 25 proteins was separated into pregnant or not on day 20 or 22. Furthermore, receiver operating characteristic curve (ROC) analysis identified five candidate proteins detecting non-pregnant heifers, of which SNX5 in day 22 serum had the highest area under the curve (AUC): 0.983. We also detected SNX5 in day 22 serum from non-pregnant heifers using western blotting. These results suggest that high SNX5 in day 22 serum could predict early pregnancy loss in heifers.

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“…In addition, it has been reported that SNX5 stimulated autophagy during viral infection 20 . In cattle, amino acids are essential for the survival and development of embryo 14,21 . Furthermore, amino acid concentrations in uterine uids during early pregnancy differ in fertile and subfertile dairy cows 22 .…”

Section: Discussionmentioning

confidence: 99%

Identification of novel candidate factor SNX5 specific for pregnancy failure in Holstein heifers

Kusama

Bai

Matsuno

et al. 2021

Preprint

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Pregnancy loss predominantly occurs during periods between blastocyst hatching and conceptus (embryo plus extraembryonic membranes) implantation to the endometrium in cattle. Insufficient biochemical communication between conceptus and endometrium has been suspected as the primary cause for early embryonic losses. If molecules regulating this communication were identified, molecular mechanisms associated with early pregnancy success or loss could be better understood. To identify novel factors as detection markers of non-pregnant or females undergoing embryonic loss, blood sera from embryo-transferred heifers on day 7 (day 0 = day of estrus) were collected on day 17, 20, or 22, which were subjected to metabolome and global proteome iTRAQ analyses. On each sample, the metabolome analysis partly divided serum components into pregnant or not. In the iTRAQ analysis, heatmap analysis with 25 unique proteins separated into pregnant or not on day 20 or 22. Furthermore, receiver operating characteristic curve (ROC) analysis identified five candidate proteins detecting non-pregnant heifers, of which SNX5 in day 22 sera had the highest area under the curve (AUC), 0.983. We also detected SNX5 in day 22 sera from non-pregnant heifers using western blotting. These results suggest that high SNX5 in day 22 sera could predict early pregnancy loss in heifers.

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Amino Acid Nutrition and Reproductive Performance in Ruminants

Cited by 35 publications

References 117 publications

Impacts of Different Prenatal Supplementation Strategies on the Plasma Metabolome of Bulls in the Rearing and Finishing Phase

Impacts of Different Prenatal Supplementation Strategies on the Plasma Metabolome of Bulls in the Rearing and Finishing Phase

Characterization of Serum Metabolome and Proteome Profiles Identifies SNX5 Specific for Pregnancy Failure in Holstein Heifers

Identification of novel candidate factor SNX5 specific for pregnancy failure in Holstein heifers

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