Amino acid mixture acutely improves the glucose tolerance of healthy overweight adults

Wang, Bei; Kammer, Lynne; Ding, Zhenping; Lassiter, David G.; Hwang, Jungyun; Nelson, Jeffrey L.; Ivy, John L.

doi:10.1016/j.nutres.2011.11.006

Cited by 12 publications

(5 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, plasma amino acids may also derive directly from the tissue turnover and protein degradation [49]. Nonetheless, postprandial amino acids are of particular interest because they appear to influence satiety [50] and glucose and insulin metabolism [51]. Despite the favorable amino acid profile of both proteins, we observed a marked postprandial increase in urea after consumption of the protein-enriched test meals.…”

Section: Discussionmentioning

confidence: 65%

Postprandial Metabolic Response to Rapeseed Protein in Healthy Subjects

et al. 2020

View full text Add to dashboard Cite

Plant proteins have become increasingly important for ecological reasons. Rapeseed is a novel source of plant proteins with high biological value, but its metabolic impact in humans is largely unknown. A randomized, controlled intervention study including 20 healthy subjects was conducted in a crossover design. All participants received a test meal without additional protein or with 28 g of rapeseed protein isolate or soy protein isolate (control). Venous blood samples were collected over a 360-min period to analyze metabolites; satiety was assessed using a visual analog scale. Postprandial levels of lipids, urea, and amino acids increased following the intake of both protein isolates. The postprandial insulin response was lower after consumption of the rapeseed protein than after intake of the soy protein (p < 0.05), whereas the postmeal responses of glucose, lipids, interleukin-6, minerals, and urea were comparable between the two protein isolates. Interestingly, the rapeseed protein exerted stronger effects on postprandial satiety than the soy protein (p < 0.05). The postmeal metabolism following rapeseed protein intake is comparable with that of soy protein. The favorable effect of rapeseed protein on postprandial insulin and satiety makes it a valuable plant protein for human nutrition.

show abstract

Section: Discussionmentioning

confidence: 65%

Postprandial Metabolic Response to Rapeseed Protein in Healthy Subjects

et al. 2020

View full text Add to dashboard Cite

show abstract

“…For example, the consumption of a beverage containing an amino acid mixture, that is, Ile, Leu, Cys, Met and Val, and carbohydrate (100 g dextrose) by healthy overweight subjects significantly increased the plasma glucagon and decreased plasma glucose response compared with the consumption of 100 g of dextrose. There were no differences in insulin responses (IR) ( 23 ) . In contrast, the amino acid mixture consisting of Leu, Ile, Val, Lys and Thr resulted in similar glycaemic and insulinaemic responses as whey in another study ( 24 ) .…”

mentioning

confidence: 95%

Impact of protein-rich meals on glycaemic response of rice

Quek

Henry

2016

Br J Nutr

View full text Add to dashboard Cite

Asians typically consume carbohydrate-rich and high-glycaemic-index diets that have been associated with an increased risk of developing type 2 diabetes. Rice is rarely eaten alone such that it is of interest to investigate the effects of co-ingesting different protein-rich meals with rice on insulin and glycaemic response. This study had a randomised, controlled, non-blind, cross-over design in which fifteen healthy Chinese male participants were required to come on non-consecutive days. Five rice-based test meals were served: rice alone (control), rice with fish (RWF), rice with egg white (RWE), rice with soya beancurd (taukwa) (RWT) and rice with chicken (RWC). The control meal consisted of 50 g of available carbohydrate, whereas all other test meals contained additional 25 g of protein.RWT was the only meal that showed significantly lower glucose response when compared with the control (P < 0·05). RWF and RWE had significantly higher insulin response, but no significant increase was observed in RWT and RWC when compared with the control (P < 0·05). RWT and RWF showed significantly higher glucagon secretion as compared with the control (P < 0·05). The four test meals studied showed varying effects, with RWT showing the greatest reduction in glycaemic response. Therefore, the ingestion of soya beancurd with rice may have a direct impact on reducing the risk in Asians transiting from being pre-diabetics to diabetics.

show abstract

“…Furthermore, the specific mix of 5AA has been shown to improve hepatic steatosis and glucose tolerance in mice [7]. In another setting, a mix of AA containing leucine, isoleucine, valine, cysteine, and methionine improved postprandial glucose responses in healthy overweight subjects [8]. When it comes to the role of AA in diabetes, Solerte et al, has shown that supplementation of the diet with all essential AA, significantly improved glucose regulation (lowered HbA1c) in poorly controlled T2DM subjects [9].…”

Section: Introductionmentioning

confidence: 99%

A drink containing amino acids and chromium picolinate improves postprandial glycemia at breakfast in healthy, overweight subjects

Östman¹,

Forslund²,

Öste³

et al. 2017

FFHD

View full text Add to dashboard Cite

Background: Chromium (Cr) and certain amino acids (AA) have individually shown to improve postprandial glycemia.Method: The present randomized, controlled, cross-over trial in 19 healthy, overweight subjects (age 51±1y and BMI 27.3±0.3 kg/m2; mean±SEM) evaluated a combination of leucine, isoleucine, valine, lysine and threonine (5AA) with Cr. Postprandial glycemia and insulinemia were measured following a bread meal, served with carbonated water (Ref) or carbonated water containing 5AA, Cr-picolinate (CrPic) or a combination (5AA+CrPic).Results: The 5AA+CrPic and 5AA, respectively, lowered the incremental glucose peak (P< 0.001) by almost 30% compared to Ref. No significant differences in incremental insulin peaks were found but, during the first 15 min, 5AA induced a higher insulin response (+112%; p<0.01) compared to Ref. Interestingly, 5AA+CrPic reduced the initial AA-induced insulin increase by more than 50%, indicating improved insulin economy. Conclusions: These observations suggest that a drink containing both 5AA and CrPic attenuate postprandial glycemia in healthy “at risk” subjects.Keywords: Amino acids, chromium picolinate, postprandial glycemia, insulin economy, drink

show abstract

Amino acid mixture acutely improves the glucose tolerance of healthy overweight adults

Cited by 12 publications

References 55 publications

Postprandial Metabolic Response to Rapeseed Protein in Healthy Subjects

Postprandial Metabolic Response to Rapeseed Protein in Healthy Subjects

Impact of protein-rich meals on glycaemic response of rice

A drink containing amino acids and chromium picolinate improves postprandial glycemia at breakfast in healthy, overweight subjects

Contact Info

Product

Resources

About