Amino acid intake and urinary zinc excretion in newborn infants receiving total parenteral nutrition

Zlotkin, Stanley; Buchanan, Barbara E.

doi:10.1093/ajcn/48.2.330

Cited by 11 publications

(8 citation statements)

References 19 publications

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“…The lack of cysteine may also decrease the infants' ability to store trace metals. Although toxicity to metals has not been observed in newborns receiving total parenteral nutrition, increased urinary trace metal excretion, as we have previosuly described, may indicate limited hepatic storage capacity (29). Neither the newborns nor the older infants in the current study received parenteral nutrients, thus we were unable to determine if the parenteral infusion of trace metals influenced metallothionein concentrations.…”

Section: Discussionmentioning

confidence: 60%

Hepatic Metallothionein as a Source of Zinc and Cysteine during the First Year of Life

Zlotkin

Cherian

1988

Pediatr Res

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ABSTRACT. Metallothionein, a high cysteine-containing protein, can bind with both essential and nonessential metals and thus play an important role as a metal storage protein and also in the detoxification of toxic metals. Although in the human fetus, levels of trace minerals and metallothionein are very high, their postnatal changes are not well documented. The purpose of the present investigation, therefore, was to quantify the accumulation of metallothionein in premature and full-term infants during the first year of life and to identify factors affecting its accumulation. From 47 postmortem samples, it was determined that hepatic metallothionein levels were highest in newborn premature and full-term infants falling to levels found in older children by 4.4 months of age. Hepatic zinc levels were also highest in the youngest infants, falling with increasing postnatal age. There was a significant positive correlation between zinc and metallothionein at all ages. However, there was a negative correlation between hepatic metallothionein levels and cystathionase activity. Hepatic copper and metallothionein levels were unrelated. The renal concentration of metallothionein, zinc, and copper were significantly lower than corresponding hepatic levels. The fall in hepatic levels of zinc and metallothionein during the first months of life correspond to a period of negative zinc balance and low endogenous cysteine production in the newborn. Thus metallothionein may play an important role as a storage depot for these two essential nutrients during this critical period of active growth. (Pediatr Res 24: 326-329, 1988) During the last trimester of pregnancy the mature placenta regulates the transfer of nutrients and protects the fetus from potentially toxic substances. With premature birth, the newborn infant is at risk of both nutrient deficiencies and toxicities for at least five reasons. I) Nutrient intake requirements may be unknown thus too much or too little may be provided; 2) homeostatic mechanisms in the functionally immature preterm are poorly developed; 3) the immature blood-brain bamer is more permeable to any elements present in the plasma; 4) growth is extremely rapid, thus nutrient needs are highest at the same time that nutrient stores are very low; and 5) postnatal adaptation may be prolonged for months even in the absence of overt disease. This combination of factors demand that both environmental and nutritional factors be rigidly controlled for the newborn premature infant.It has been established that most of the minerals of the human fetus are layed down during the last trimester of pregnancy (1).

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Section: Discussionmentioning

confidence: 60%

Hepatic Metallothionein as a Source of Zinc and Cysteine during the First Year of Life

Zlotkin

Cherian

1988

Pediatr Res

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“…For manganese the highest concentration was 47.72 mg kg -1 and was recorded in genotype ITOOK-1060. This value was much higher than the values reported by Ano and Ubonchi (2008) (Zlotkin and Buchanan, 1988). It was also reported that zinc dependent enzymes are involved in macronutrient metabolism and cell replication (Arinola, 2008).…”

Section: Analysis Of Variance For Nutritional Valuesmentioning

confidence: 51%

Nutritional composition of immature pods in selected cowpea [Vigna unguiculata (L.) Walp.] genotypes in South Africa

Gerrano¹,

Rensburg²,

Adebola³

2017

Aust J Crop Sci

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Information on genetic variability among genotypes is useful in crop improvement programmes. The study was carried out to determine the variability of nutritional composition in the immature pods of selected cowpea genotypes for use in breeding for nutritional qualities. ). The multivariate analysis showed wide genetic variability among the genotypes which could be exploited in selecting suitable parents when breeding for nutritional qualities. High heritability estimates were also observed in most of the traits evaluated indicating potential genetic gain when breeding for these traits. The present study revealed the genetic potential of the genotypes studied and their importance for use in the breeding programme aimed towards combating nutritional deficiencies and food insecurity in South Africa.

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“…Cystine and histidine have the highest affinity to zinc among the other amino acids. Glutamine, lysine, and tyrosine also can bind zinc, but to a lesser degree [5].…”

Section: Discussionmentioning

confidence: 99%

“…Hyperzincuria is also seen in sickle cell anemia, cirrhosis, diabetes mellitus, severe trauma, and in patients under total parenteral nutrition (TPN) [3][4][5][6]. In some of these conditions, hyperzincuria is accompanied by aminoaciduria.…”

Section: Introductionmentioning

confidence: 99%

Hyperzincuria and selective aminoaciduria in thalassemia

rmak

Kemahl

Diner

et al. 2000

J. Trace Elem. Exp. Med.

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Amino acid intake and urinary zinc excretion in newborn infants receiving total parenteral nutrition

Cited by 11 publications

References 19 publications

Hepatic Metallothionein as a Source of Zinc and Cysteine during the First Year of Life

Hepatic Metallothionein as a Source of Zinc and Cysteine during the First Year of Life

Nutritional composition of immature pods in selected cowpea [Vigna unguiculata (L.) Walp.] genotypes in South Africa

Hyperzincuria and selective aminoaciduria in thalassemia

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