Amino acid infusions and urinary zinc excretion

Hyperzincuria and selective aminoaciduria in thalassemia

“…Under normal conditions, ultrafiltrated zinc is almost totaly reabsorbed from distal tubules, and only 1-2% is excreted via urine [7]. It is reported that when the plasma levels of amino acids are altered with amino acid infusions, ultrafiltrated fraction of zinc is increased in the kidneys [7].…”

“…The importance of the kidneys in the maintenance of zinc homeostasis and the factors controlling urinary excretion have not been clearly defined as yet [7]. In this study, it was determined that the increase in urinary loss of some amino acids, especially those with affinity to zinc, was concomitant with hyperzincuria.…”

“…It is reported that when the plasma levels of amino acids are altered with amino acid infusions, ultrafiltrated fraction of zinc is increased in the kidneys [7].…”

Correlation between Intravenously Supplied Energy Level and Zinc Metabolism in Laparotomized Rats.

“…Urinary zinc excretion is stimulated by the infusion of amino acid. The mechanism of the increase of urinary zinc excretion caused by the infusion of sugar-amine compounds has been suggested to be the chelating action of those compounds (6,7). Other important factors are associated with a patient's condition (e.g., catabolism).…”

“…The topical symptom of zinc deficiency is skin lesions which are improved rapidly by the administration of zinc. The causes of zinc deficiency derived from the infusion solution administered as part of TPN are thought to be the amino acid (5), sugar-amine compounds (6,7) and low zinc content in the TPN solution (8). Urinary zinc excretion is stimulated by the infusion of amino acid.…”