Amino acid digestibility in pigs with signs of porcine intestinal adenomatosis

Rowan, T.G.; Tl, Lawrence

doi:10.1136/vr.110.13.306

Cited by 9 publications

(4 citation statements)

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“…Hypoproteinaemia was the most consistent laboratory finding observed in the present study and was used in suspected cases as a rapid screening procedure to identify suspected cases of equine PE. There is some evidence that hypoproteinaemia in pigs with PE results from intestinal protein loss and malabsorption of amino acids; normal protein metabolism is observed following the alleviation of digestive signs (Nielsen 1966;Rowan and Lawrence 1982). Increased protein catabolism may have also contributed to hypoproteinaemia in our foals.…”

Section: Discussionmentioning

confidence: 96%

Equine proliferative enteropathy: a cause of weight loss, colic, diarrhoea and hypoproteinaemia in foals on three breeding farms in Canada

Lavoie¹,

Drolet

Parsons

et al. 2000

Equine Veterinary Journal

110

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Summary Proliferative enteropathy (PE) is a transmissible enteric disease caused by Lawsonia intracellularis. An outbreak of equine PE was diagnosed in foals from 3 breeding farms. Most foals had been weaned prior to the appearance of clinical signs, which included depression, rapid and marked weight loss, subcutaneous oedema, diarrhoea and colic. Poor body condition with a rough haircoat and a potbellied appearance were common findings in affected foals. Respiratory tract infection, dermatitis and intestinal parasitism were also found in some foals. Haematological and plasma biochemical abnormalities included hypoproteinaemia, transient leucocytosis, anaemia and increased serum creatinine kinase concentration. Postmortem diagnosis of PE was confirmed on 4 foals based on the presence of characteristic intracellularbacteria within the apical cytoplasm of proliferating crypt epithelial cells of the intestinal mucosa, using silver stains, and by results of PCR analysis and immunohistochemistry. Antemortem diagnosis of equine PE was based on the clinical signs, hypoproteinaemia and the exclusion of common enteric infections. Faecal PCR analysis was positive for the presence of L. intracellularis in 6 of 18 foals tested while the serum of all 7 foals with PE serologically evaluated had antibodies against L. intracellularis. Most foals were treated with erythromycin estolate alone or combined with rifampin for a minimum of 21 days. Additional symptomatic treatments were administered when indicated. All but one foal treated with erythromycin survived the infection. This study indicates that equine PE should be included in the differential diagnosis of outbreaks of rapid weight loss, diarrhoea, colic and hypoproteinaemia in weanling foals.

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Section: Discussionmentioning

confidence: 96%

Equine proliferative enteropathy: a cause of weight loss, colic, diarrhoea and hypoproteinaemia in foals on three breeding farms in Canada

Lavoie¹,

Drolet

Parsons

et al. 2000

Equine Veterinary Journal

110

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“…Hypoproteinaemia (4/4) was the most consistent finding in the foals of this report. There is evidence that hypoproteinaemia in pigs infected with L. intracellularis is due to intestinal protein loss and malabsorption of amino acids (Nielsen 1966;Rowan and Lawrence 1982). Factors that predispose pigs and weanling foals to proliferative enteropathy are unknown but it has been suggested that young animals are protected by colostral immunity and older animals may be immune due to previous exposure to the bacterium (Winkelman 1996).…”

Section: Discussionmentioning

confidence: 99%

Outbreak of Lawsonia intracellularis on a Standardbred breeding farm in North Carolina

Merlo

Sheats

Elce

et al. 2009

Equine Veterinary Education

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Summary Lawsonia intracellularis is a cause of protein‐losing enteropathy in weanling foals commonly causing signs including diarrhoea, oedema and unthrifty appearance. It has previously been reported as sporadic cases throughout the USA, Canada and Europe. Only recently have outbreaks on a single farm location been reported. The cases reported here are an example of multiple foals on a single farm testing serologically positive for L. intracellularis. These foals ranged in severity from asymptomatic to severely hypoproteinaemic and septic; however, none of the foals ever displayed diarrhoea, which is the most common presenting sign of this disease process.

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“…PIA is rarely fatal and is more often associated with post-weaning illthrift (Rowland and Rowntree 1972;Jonssrm and Martinsson 1976;Roberts el al 1977). It has also been shown that PIA can be associated with malabsorption of dietary amino acids (Rowan and Lawrence 1982). Lesions of PIA may resolve and be undetectable at slaughter.…”

mentioning

confidence: 99%

Suboptimal growth associated with porcine intestinal adenomatosis in pigs in nutritional studies

1991

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Amino acid digestibility in pigs with signs of porcine intestinal adenomatosis

Cited by 9 publications

References 0 publications

Equine proliferative enteropathy: a cause of weight loss, colic, diarrhoea and hypoproteinaemia in foals on three breeding farms in Canada

Equine proliferative enteropathy: a cause of weight loss, colic, diarrhoea and hypoproteinaemia in foals on three breeding farms in Canada

Outbreak of Lawsonia intracellularis on a Standardbred breeding farm in North Carolina

Suboptimal growth associated with porcine intestinal adenomatosis in pigs in nutritional studies

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