Amino acid derived biopolymers: Recent advances and biomedical applications

Gupta, Sachchidanand Soaham; Mishra, Vivek; Mukherjee, Maumita Das; Saini, Parveen; Ranjan, Kumar Rakesh

doi:10.1016/j.ijbiomac.2021.08.036

Cited by 55 publications

(52 citation statements)

References 231 publications

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“…Natural amino acid-derived polymers are recognized as promising materials to understand the structures and functions of proteins and develop bioinspired functional biomaterials for use in biomimicry, drug delivery, and tissue engineering applications 1 – 3 . Among them, poly(amino acid)s (PAAs) have attracted increasing attention due to their good biocompatibility, nontoxic metabolized products, and specific secondary conformations such as α-helix and β-sheet 4 – 10 .…”

Section: Introductionmentioning

confidence: 99%

Intrinsically fluorescent polyureas toward conformation-assisted metamorphosis, discoloration and intracellular drug delivery

et al. 2022

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Peptidomimetic polymers have attracted increasing interest because of the advantages of facile synthesis, high molecular tunability, resistance to degradation, and low immunogenicity. However, the presence of non-native linkages compromises their ability to form higher ordered structures and protein-inspired functions. Here we report a class of amino acid-constructed polyureas with molecular weight- and solvent-dependent helical and sheet-like conformations as well as green fluorescent protein-mimic autofluorescence with aggregation-induced emission characteristics. The copolymers self-assemble into vesicles and nanotubes and exhibit H-bonding-mediated metamorphosis and discoloration behaviors. We show that these polymeric vehicles with ultrahigh stability, superfast responsivity and conformation-assisted cell internalization efficiency could act as an “on-off” switchable nanocarrier for specific intracellular drug delivery and effective cancer theranosis in vitro and in vivo. This work provides insights into the folding and hierarchical assembly of biomacromolecules, and a new generation of bioresponsive polymers and nonconventional luminescent aliphatic materials for diverse applications.

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Section: Introductionmentioning

confidence: 99%

Intrinsically fluorescent polyureas toward conformation-assisted metamorphosis, discoloration and intracellular drug delivery

et al. 2022

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“…Amino acids are the basic unit of biological functional macromolecular proteins and the basic material of proteins required by animal nutrition. Amino acids are classified according to their side-chain groups and can be divided into polar amino acids and non-polar amino acids, of which polar amino acids can be divided into basic amino acids, acidic amino acids, and neutral amino acids [ 89 ], as shown in Figure 6 . Poly amino acids are a kind of natural protein mimic, which have the same primary structure as natural proteins and polypeptide materials, and some poly amino acids can also simulate their secondary structure.…”

Section: Amino Acidmentioning

confidence: 99%

A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

Song

et al. 2022

Biomolecules

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The timely and effective control and repair of wound bleeding is a key research issue all over the world. From traditional compression hemostasis to a variety of new hemostatic methods, people have a more comprehensive understanding of the hemostatic mechanism and the structure and function of different types of wound dressings. Electrospun nanofibers stand out with nano size, high specific surface area, higher porosity, and a variety of complex structures. They are high-quality materials that can effectively promote wound hemostasis and wound healing because they can imitate the structural characteristics of the skin extracellular matrix (ECM) and support cell adhesion and angiogenesis. At the same time, combined with amino acid polymers with good biocompatibility not only has high compatibility with the human body but can also be combined with a variety of drugs to further improve the effect of wound hemostatic dressing. This paper summarizes the application of different amino acid electrospun wound dressings, analyzes the characteristics of different materials in preparation and application, and looks forward to the development of directions of poly(amino acid) electrospun dressings in hemostasis.

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“…The chymotrypsin enzyme catalyzes the hydrolysis of proteins by cleaving the molecules at hydrophobic amino acid residues, such as the L-isomers of tyrosine, phenylalanine, and tryptophan. It also has the capability of acting on amides and esters of susceptible amino acids [ 47 ]. The use of these enzymes can result in the one key advantages of this approach, which is the reproducibility of the process such that similar proteins and hydrolysates products are generated.…”

Section: Process Of Generation and Isolation Of Bioactive Peptidesmentioning

confidence: 99%

Bioactive Peptides from Algae: Traditional and Novel Generation Strategies, Structure-Function Relationships, and Bioinformatics as Predictive Tools for Bioactivity

et al. 2022

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Over the last decade, algae have been explored as alternative and sustainable protein sources for a balanced diet and more recently, as a potential source of algal-derived bioactive peptides with potential health benefits. This review will focus on the emerging processes for the generation and isolation of bioactive peptides or cryptides from algae, including: (1) pre-treatments of algae for the extraction of protein by physical and biochemical methods; and (2) methods for the generation of bioactive including enzymatic hydrolysis and other emerging methods. To date, the main biological properties of the peptides identified from algae, including anti-hypertensive, antioxidant and anti-proliferative/cytotoxic effects (for this review, anti-proliferative/cytotoxic will be referred to by the term anti-cancer), assayed in vitro and/or in vivo, will also be summarized emphasizing the structure–function relationship and mechanism of action of these peptides. Moreover, the use of in silico methods, such as quantitative structural activity relationships (QSAR) and molecular docking for the identification of specific peptides of bioactive interest from hydrolysates will be described in detail together with the main challenges and opportunities to exploit algae as a source of bioactive peptides.

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Amino acid derived biopolymers: Recent advances and biomedical applications

Cited by 55 publications

References 231 publications

Intrinsically fluorescent polyureas toward conformation-assisted metamorphosis, discoloration and intracellular drug delivery

Intrinsically fluorescent polyureas toward conformation-assisted metamorphosis, discoloration and intracellular drug delivery

A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

Bioactive Peptides from Algae: Traditional and Novel Generation Strategies, Structure-Function Relationships, and Bioinformatics as Predictive Tools for Bioactivity

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