Amino acid concentrations in chinchilla cochlear nucleus at different times after carboplatin treatment

Godfrey, Donald A.; Godfrey, Matthew A.; Ding, Dalian; Chen, Kejian; Salvi, Richard

doi:10.1016/j.heares.2005.03.004

Cited by 11 publications

(11 citation statements)

References 25 publications

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“…Cochlear ablation, by contrast, induces enhanced glutamate metabolism, manifesting as elevated release and uptake, and concomitant with a putative compensatory strengthening of excitatory processing following extensive afferent fiber death (Potashner et al, 1997; Illing et al, 2005), as levels of glutamate and aspartate in the CN correlate with the degree of cochlear damage (Godfrey et al, 2005, 2014). While the proportional expression of glutamate vesicular transporter (VGLUT) subtypes has been reported to undergo adjustment in the insult-exposed CN (Fyk-Kolodziej et al, 2011), work specifically directed at such changes in the dorsal cochlear nucleus (DCN) has unveiled marked crossmodal reweighing.…”

Section: Neurochemical and Structural Changes Induced By Auditory Damagementioning

confidence: 99%

Insult-induced adaptive plasticity of the auditory system

Gold

Bajo

2014

Front. Neurosci.

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The brain displays a remarkable capacity for both widespread and region-specific modifications in response to environmental challenges, with adaptive processes bringing about the reweighing of connections in neural networks putatively required for optimizing performance and behavior. As an avenue for investigation, studies centered around changes in the mammalian auditory system, extending from the brainstem to the cortex, have revealed a plethora of mechanisms that operate in the context of sensory disruption after insult, be it lesion-, noise trauma, drug-, or age-related. Of particular interest in recent work are those aspects of auditory processing which, after sensory disruption, change at multiple—if not all—levels of the auditory hierarchy. These include changes in excitatory, inhibitory and neuromodulatory networks, consistent with theories of homeostatic plasticity; functional alterations in gene expression and in protein levels; as well as broader network processing effects with cognitive and behavioral implications. Nevertheless, there abounds substantial debate regarding which of these processes may only be sequelae of the original insult, and which may, in fact, be maladaptively compelling further degradation of the organism's competence to cope with its disrupted sensory context. In this review, we aim to examine how the mammalian auditory system responds in the wake of particular insults, and to disambiguate how the changes that develop might underlie a correlated class of phantom disorders, including tinnitus and hyperacusis, which putatively are brought about through maladaptive neuroplastic disruptions to auditory networks governing the spatial and temporal processing of acoustic sensory information.

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Section: Neurochemical and Structural Changes Induced By Auditory Damagementioning

confidence: 99%

Insult-induced adaptive plasticity of the auditory system

Gold

Bajo

2014

Front. Neurosci.

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“…Glutamate level and synthesis data in VCN after carboplatin resembled those for cochlear ablation except for a slower progression. To some extent, this slower progression paralleled a slower progression of the cochlear damage following carboplatin administration ( 12 ). At the mid time, inner hair cell loss was partial.…”

Section: Notable Chemical Changes After Cochlear Damagementioning

confidence: 99%

“…One study ( 6 ) found similar behaviorally measured tinnitus symptoms in chinchillas associated with three different patterns of cochlear damage following acoustic exposure, cisplatin, and carboplatin treatments. In our previous studies, we have found different effects on central auditory system neurotransmitter systems of different types of cochlear damage, including partial damage from acoustic trauma ( 7 – 10 ) and carboplatin treatment ( 11 , 12 ), both of which have been associated with tinnitus ( 2 , 13 ), and complete destruction via cochlear ablation ( 14 – 17 ). Cochlear ablation produces complete transection of auditory nerve fibers, which has been associated with tinnitus ( 18 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

Cochlear Damage Affects Neurotransmitter Chemistry in the Central Auditory System

Lee

Godfrey

2014

Front. Neurol.

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Tinnitus, the perception of a monotonous sound not actually present in the environment, affects nearly 20% of the population of the United States. Although there has been great progress in tinnitus research over the past 25 years, the neurochemical basis of tinnitus is still poorly understood. We review current research about the effects of various types of cochlear damage on the neurotransmitter chemistry in the central auditory system and document evidence that different changes in this chemistry can underlie similar behaviorally measured tinnitus symptoms. Most available data have been obtained from rodents following cochlear damage produced by cochlear ablation, intense sound, or ototoxic drugs. Effects on neurotransmitter systems have been measured as changes in neurotransmitter level, synthesis, release, uptake, and receptors. In this review, magnitudes of changes are presented for neurotransmitter-related amino acids, acetylcholine, and serotonin. A variety of effects have been found in these studies that may be related to animal model, survival time, type and/or magnitude of cochlear damage, or methodology. The overall impression from the evidence presented is that any imbalance of neurotransmitter-related chemistry could disrupt auditory processing in such a way as to produce tinnitus.

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“…Damage can result from aging (Nicolas-Puel et al, 2002) or exposure to noise, the cancer drugs carboplatin and cisplatin (Ding et al, 1999; Godfrey et al, 2005; Hofstetter et al, 1997; Husain et al, 2001; Klis et al, 2002; Stengs et al, 1998), styrene (Chen et al, 2008) or other agents. Systemic administration of the drug salicylate can induce temporary tinnitus (Stolzberg et al, 2011; Sun et al, 2009; Wei et al, 2010; Yang et al, 2007).…”

Section: The Problem Of Tinnitusmentioning

confidence: 99%

Understanding tinnitus: The dorsal cochlear nucleus, organization and plasticity

et al. 2012

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Tinnitus, the perception of a phantom sound, is a common consequence of damage to the auditory periphery. A major goal of tinnitus research is to find the loci of the neural changes that underlie the disorder. Crucial to this endeavor has been the development of an animal behavioral model of tinnitus, so that neural changes can be correlated with behavioral evidence of tinnitus. Three major lines of evidence implicate the dorsal cochlear nucleus (DCN) in tinnitus. First, elevated spontaneous activity in the DCN is correlated with peripheral damage and tinnitus. Second, there are somatosensory inputs to the DCN that can modulate spontaneous activity and might mediate the somatic-auditory interactions seen in tinnitus patients. Third, we have found a subpopulation of DCN neurons in the adult rat that express doublecortin, a plasticity-related protein. The expression of this protein may reflect a role of these neurons in the neural reorganization causing tinnitus. However, there is a problem in extending the findings in the rodent DCN to humans. Classic studies state that the structure of the primate DCN is quite different from that of rodents, with primates lacking granule cells, the recipients of somatosensory input. To address the possibility of major species differences in DCN organization, we compared Nissl-stained sections of the DCN in five different species. In contrast to earlier reports, our data suggest that the organization of the primate DCN is not dramatically different from that of the rodents, and validate the use of animal data in the study of tinnitus.

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Amino acid concentrations in chinchilla cochlear nucleus at different times after carboplatin treatment

Cited by 11 publications

References 25 publications

Insult-induced adaptive plasticity of the auditory system

Insult-induced adaptive plasticity of the auditory system

Cochlear Damage Affects Neurotransmitter Chemistry in the Central Auditory System

Understanding tinnitus: The dorsal cochlear nucleus, organization and plasticity

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