Amino acid catabolism in environmental extremes: effect of high altitude and calories

Whitten, Bertwell K.; Burlington, RF; Packham, MA; Sidel, CM; Beecher, G. R.

doi:10.1152/ajplegacy.1970.218.5.1346

Cited by 5 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sustained hypo-baric hypoxia induces anorexia (Hamad and Travis 2006; Tschop and Morrison 2001), catabolism (Consolazio et al 1972; Larsen et al 1997; Whitten et al 1970), and, at ambient temperatures lower than an organism’s thermoregulatory set point, a fall in metabolic rate (Gautier 1996; Kellogg 1978), adaptations that lead to lower body mass (Zhou et al 2007) and energy conservation. Another adaptive response to chronic hypoxia is an overall shift toward carbohydrate oxidation, supposedly because more ATP is produced from glucose than from lipid per O 2 molecule consumed (Braun 2008).…”

Section: Effects Of Intermittent Hypoxia: Evidence From Animal Modelsmentioning

confidence: 99%

Metabolic Consequences of Sleep-Disordered Breathing

Jun¹,

Polotsky²

2009

ILAR Journal

View full text Add to dashboard Cite

There is increasing evidence of a causal relationship between sleep-disordered breathing and metabolic dysfunction. Metabolic syndrome (MetS), a cluster of risk factors that promote atherosclerotic cardiovascular disease, comprises central obesity, insulin resistance, glucose intolerance, dyslipidemia, and hypertension, manifestations of altered total body energy regulation. Excess caloric intake is indisputably the key driver of MetS, but other environmental and genetic factors likely play a role; in particular, obstructive sleep apnea (OSA), characterized by intermittent hypoxia (IH), may induce or exacerbate various aspects of MetS. Clinical studies show that OSA can affect glucose metabolism, cholesterol, inflammatory markers, and nonalcoholic fatty liver disease. Animal models of OSA enable scientists to circumvent confounders such as obesity in clinical studies. In the most widely used model, which involves exposing rodents to IH during their sleep phase, the IH alters circadian glucose homeostasis, impairs muscle carbohydrate uptake, induces hyperlipidemia, and upregulates cholesterol synthesis enzymes. Complicating factors such as obesity or a high-fat diet lead to progressive insulin resistance and liver inflammation, respectively. Mechanisms for these effects are not yet fully understood, but are likely related to energy-conserving adaptations to hypoxia, which is a strong catabolic stressor. Finally, IH may contribute to the morbidity of MetS by inducing inflammation and oxidative stress. Identification of OSA as a potential causative factor in MetS would have immense clinical impact and could improve the management and understanding of both disorders.

show abstract

Section: Effects Of Intermittent Hypoxia: Evidence From Animal Modelsmentioning

confidence: 99%

Metabolic Consequences of Sleep-Disordered Breathing

Jun¹,

Polotsky²

2009

ILAR Journal

View full text Add to dashboard Cite

show abstract

“…It would be necessary to construct an intuitive graphical user interface before this tool would be viable for use in the archaeological or historical community. For algorithm adjustments, there is evidence that higher altitudes may affect the caloric requirements and metabolic rate of humans [37,44]. It would be interesting to include an altitude factor when determining energetic paths in these environments.…”

Section: California Archaeological Sitesmentioning

confidence: 99%

Energetic Path Finding Across Massive Terrain Data

Tsui

View full text Add to dashboard Cite

Energetic Path Finding Across Massive Terrain Data Andrew TsuiBefore there were airplanes, cars, trains, boats, or bicycles, the primary means of transportation was on foot. Unfortunately, many of the trails used by ancient travelers have long since been abandoned. We present a software tool which can help visualize and predict where these forgotten trails might lie through the use of a human-centered cost metric. By comparing the paths generated by our software with known historical trails, we demonstrate how the tool can indicate likely trails used by ancient travelers. In addition, this new tool provides novel visualizations to better help the user understand alternate paths, effect of terrain, and nearby areas of interest. Such a tool could be used by archaeologists and historians to better visualize and understand the terrain and paths around sites of historical interest.This thesis is a continuation of previous work, with emphasis on the ability to generate paths which traverse several thousand kilometers. To accomplish this, various graph simplification and path approximation algorithms are explored to construct a real-time path finding algorithm. To this end, we show that it is possible to restrict the search space for a path finding algorithm while not disrupting accuracy. Combined with a multi-threaded variant of Dijkstra's shortest path algorithm, we present a tool capable of traversing the contiguous US, a dataset containing over 19 billion datapoints, in under three hours on a 2.5 Ghz dual core processor. The tool is demonstrated on several examples which show the potential archaeological and historical applicability, and provide avenues for future improvements.iv

show abstract

Physiological Effects of Environmental Stimuli

Buckley

1972

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Amino acid catabolism in environmental extremes: effect of high altitude and calories

Cited by 5 publications

References 0 publications

Metabolic Consequences of Sleep-Disordered Breathing

Metabolic Consequences of Sleep-Disordered Breathing

Energetic Path Finding Across Massive Terrain Data

Physiological Effects of Environmental Stimuli

Contact Info

Product

Resources

About