Amino acid-based Poly(ester urea) copolymer films for hernia-repair applications

Dreger, Nathan Z.; Fan, Zhihai; Zander, Zachary K.; Tantisuwanno, Chinnapatch; Haines, Molly C.; Waggoner, Morgan; Parsell, Trenton H.; Søndergaard, Claus S.; Hiles, Michael C.; Premanandan, Christopher; Becker, Matthew L.

doi:10.1016/j.biomaterials.2018.08.003

Cited by 25 publications

(17 citation statements)

References 42 publications

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“…Amino acid-based poly(ester urea)s (PEUs) in particular are a class of highly tunable, amorphous degradable polymers that have been shown in vivo to have a limited inflammatory response over several months in a number of promising preclinical studies including tissue engineered vascular grafts, hernia and rotator cuff repair, , and surgical adhesion barriers . PEUs possess a great deal of flexibility in their chemical structure and mechanical properties due to the amino acid side group, the incorporated diol, and the copolymer stoichiometry .…”

Section: Biodegradable Polymers: Materials Selectionmentioning

confidence: 99%

Fabrication of Biomedical Scaffolds Using Biodegradable Polymers

et al. 2021

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Degradable polymers are used widely in tissue engineering and regenerative medicine. Maturing capabilities in additive manufacturing coupled with advances in orthogonal chemical functionalization methodologies have enabled a rapid evolution of defect-specific form factors and strategies for designing and creating bioactive scaffolds. However, these defect-specific scaffolds, especially when utilizing degradable polymers as the base material, present processing challenges that are distinct and unique from other classes of materials. The goal of this review is to provide a guide for the fabrication of biodegradable polymer-based scaffolds that includes the complete pathway starting from selecting materials, choosing the correct fabrication method, and considering the requirements for tissue specific applications of the scaffold.

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Section: Biodegradable Polymers: Materials Selectionmentioning

confidence: 99%

Fabrication of Biomedical Scaffolds Using Biodegradable Polymers

et al. 2021

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“…The hydrolysis (degradation) reaction is modeled by the bond-breaking events, and its acceptance or rejection is governed by the Monte Carlo scheme. In particular, we focus on the effect of hydrophobic and hydrophilic group distribution on degradation of glycine-based poly(ester urea), valine-based poly(ester urea), and phenylalanine-based poly(ester urea) polymers. ,− …”

Section: Introductionmentioning

confidence: 99%

Degradation of Films of Block Copolymers: Molecular Dynamics Simulations

et al. 2020

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Coarse-grained molecular dynamics simulations are used to study the degradation of films of copolymers in a selective solvent for one of the blocks. Simulations were designed to mimic the hydrolytic degradation of glycine, valine, and phenylalanine-based poly(ester urea)s. The analysis of the simulation results shows that the rate of copolymer degradation is a result of the interplay between chain-breaking kinetics, solvent diffusion, and swelling of the solvophilic domains. The evolution of the film structure during the degradation process was monitored by calculating the scattering function S(q) of the copolymer film. In the initial stages of the polymer degradation and swelling, the scattering function has a characteristic peak corresponding to a domain spacing of solvophilic and solvophobic domains. The solvent diffusion into the films results in a monotonic shift of the peak position to smaller q. This shift is accompanied by the increase in the scattering intensity at q ≪ 1 in such a way that the peak completely disappears at the later stages of film degradation with the function S(q) having two characteristic scaling regimes: S(q) ∼ 1/q 2 and S(q) ∼ 1/q 4 . At this stage of film degradation, the film is composed of the interconnected network of solvophobic domains. The number and weight average degree of polymerizations (DPs) of the copolymer fragments monotonically decrease with time. However, the dispersity (Đ) shows a nonmonotonic dependence. The copolymer degradation kinetics allows for universal description of the time dependence of the copolymer DP and the dispersity in terms of the fraction of the broken bonds.

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“…5). The granuloma was less than 200 μm thick for all samples, which has previously been reported as acceptable in terms of tissue compatibility for long-term implants 4,33,34 . This is indicative of the tunable degradation profiles from varied succinate content as increasing implant degradation rates correlates with greater cellular remodeling processes 34 .…”

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Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering

Wandel

Bell

et al. 2021

Nat Commun

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Complex biological tissues are highly viscoelastic and dynamic. Efforts to repair or replace cartilage, tendon, muscle, and vasculature using materials that facilitate repair and regeneration have been ongoing for decades. However, materials that possess the mechanical, chemical, and resorption characteristics necessary to recapitulate these tissues have been difficult to mimic using synthetic resorbable biomaterials. Herein, we report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone. These features afford concomitant control over the mechanical and surface eroding degradation properties of these materials. We show the materials can be functionalized post-polymerization with bioactive species and enhance cell adhesion. Furthermore, an in vivo rat model demonstrates that degradation and resorption are dependent on succinate stoichiometry in the elastomers and the results show limited inflammation highlighting their potential for use in soft tissue regeneration and drug delivery.

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Amino acid-based Poly(ester urea) copolymer films for hernia-repair applications

Cited by 25 publications

References 42 publications

Fabrication of Biomedical Scaffolds Using Biodegradable Polymers

Fabrication of Biomedical Scaffolds Using Biodegradable Polymers

Degradation of Films of Block Copolymers: Molecular Dynamics Simulations

Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering

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