In the last chapter, the authors focused on the protocols involving the synthesis of amines from a sustainable perspective, in unconventional solvents such as water and deep eutectic solvents (DESs). Also, in the second part of this chapter, the applications of amines in different areas were reviewed. DESs are a new class of ionic solvents that were introduced in 2003. In recent years, DESs have attracted attention due to their excellent biodegradability, low volatility, nontoxicity, easy preparation, and low preparation costs. These interesting features of DESs have made these natural green solvents more popular in electrochemistry, materials chemistry, and organic synthesis. DESs are mainly prepared by combining choline chloride with different hydrogen bond donors, such as urea, or Lewis acids, such as zinc chloride.