Amine Precursors and Depression

Mendels, J.

doi:10.1001/archpsyc.1975.01760190024002

Cited by 114 publications

(30 citation statements)

References 90 publications

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“…85-92) of a reduced probenecid rise of CSF 5 HI A A basal levels in endogenous depressed patients. The identification of unipolar depressive patients with weak central 5HT turnover rate is of importance in light of the good therapeutic results described with ¿-trytophan (LTRY) (Ashcroft et al, 1973a, b;Bourne et al, 1968;Coppen et al, 1967Coppen et al, , 1972Wirz-Justice, 1976) or 5-hydroxytryptophan (5HTRY) (Persson and Roos, 1967;Van Praag et al, 1972;WirzJustice, 1976) in some depressed patients, al though these results are not universally accep ted (Mendels et al, 1975;Olsson and Roos, 1968;Wirz-Justice, 1976). Furthermore, the mean CSF HVA basal levels and the mean HVA increase after probenecid are within normal ranges in the unipolar depressed group.…”

Section: Discussionmentioning

confidence: 99%

Biogenic Amine Disturbances in Cerebrospinal Fluid in Parkinsonism and Unipolar Depression: Use of the Probenecid Method

Vanderheyden¹,

Noel²,

Mendlewicz³

1981

Neuropsychobiology

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Probenecid was administered to 7 unipolar depressed patients, 7 parkinsonians and 7 extrapyramidal patients with senile dementia matched for age and sex. Before and after the administration of probenecid, the levels of 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) were determined in the cerebrospinal fluid (CSF) of all patients in order to study the central turnover rate of serotonin and dopamine. Unipolar depressed patients showed a significantly lower increase in CSF 5HIAA levels after probenecid than parkinsonians. Patients with parkinsonism had a reduced increment of CSF HVA levels following probenecid administration when compared to unipolar depressed and extrapyramidal patients with senile dementia. The authors conclude that the biochemical study of CSF biogenic amines using the probenecid method can be used as a highly sensitive biological screening test for diagnosing Parkinson and depressive syndromes among an aging population of retarded, tremoring, rigid and hypokinetic patients.

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Section: Discussionmentioning

confidence: 99%

Biogenic Amine Disturbances in Cerebrospinal Fluid in Parkinsonism and Unipolar Depression: Use of the Probenecid Method

Vanderheyden¹,

Noel²,

Mendlewicz³

1981

Neuropsychobiology

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“…Os precursores da serotonina, L-triptofano e 5-hidroxitriptofano (5-HTP), foram estudados em transtornos depressivos com resultados contraditórios (Mendels et al, 1975;Byerley et al, 1987;Young, 1991;Shaw et al, 2001). Alguns ensaios clínicos com amostras pequenas usando L-triptofano mostraram potencialização dos IMAOs e dos antidepressivos serotoninérgicos em pacientes com depressão refretária (Nível C) (Coppen et al, 1963;Glassman e Platman, 1969;Ayuso Gutierrez e Alino, 1971).…”

Section: Outras Estratégias De Potencialização Farmacológicaunclassified

Diretrizes da World Federation of Societies of Biological Psychiatry (WFSBP) para tratamento biológico de transtornos depressivos unipolares, 1ª parte: tratamento agudo e de continuação do transtorno depressivo maior

Bauer¹,

Whybrow²,

Angst³

et al. 2009

Rev. psiquiatr. clín.

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“…However, the role of DA, notwithstanding its evident relationship with motoricity and humour, has not yet been studied in sufficient detail essentially because of the difficulties involved both in the use of ¿-dopa and of ¿-dopa plus a decarboxylase inhibitor (29).…”

Section: Studies On Depressive Syndromesmentioning

confidence: 99%

Restatement and Prospectives of Ergot Alkaloids in Clinical Neurology and Psychiatry

1978

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The pharmacological action of the ergot alkaloids on the brain, except for the well-known hallucinogenic effects, has never been well understood. If we exclude the documented α-adrenolytic action and the central nervous system depression, nothing has been described with certainty. However, therapeutically, a pharmacologic action could be documented both in the elderly and in chronic cerebrovascular disorders, such as reduction in subjective symptomatology and overall improvement in the autonomy. This was generally associated with a psychotonic action. Considering these results for many years, researchers have been attempting to demonstrate the pharmacological action of ergot alkaloids on the cerebral circulation and metabolism. It has, therefore, been wished to demonstrate the effect on the cerebral blood flow, the metabolism and the EEC The possibility of a psychopharmacological effect, whose mode of action could not be evidenced evaluating parameters using such coarse techniques, has been demonstrated. In our view, the new dimension shown by bromocriptine is in accordance with these considerations. Therefore, our presentation should be restricted to the results and the prospectives opened by bromocriptine in neuropsychiatry. We shall report our personal results obtained in parkinsonism, degenerative chorea and the depressive syndromes. Studies in progress in the elderly and in epilepsy will also be reported.

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Amine Precursors and Depression

Cited by 114 publications

References 90 publications

Biogenic Amine Disturbances in Cerebrospinal Fluid in Parkinsonism and Unipolar Depression: Use of the Probenecid Method

Biogenic Amine Disturbances in Cerebrospinal Fluid in Parkinsonism and Unipolar Depression: Use of the Probenecid Method

Diretrizes da World Federation of Societies of Biological Psychiatry (WFSBP) para tratamento biológico de transtornos depressivos unipolares, 1ª parte: tratamento agudo e de continuação do transtorno depressivo maior

Restatement and Prospectives of Ergot Alkaloids in Clinical Neurology and Psychiatry

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