Amine functionalized ZrO<sub>2</sub>nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging

Tahir, Muhammad Nawaz; Ragg, Ruben; Natálio, Filipe; Sahoo, Jugal Kishore; Daniel, Phillip; Koynov, Kaloian; Strand, Dennis; Strand, Susanne; Tremel, Wolfgang

doi:10.1039/c4tb01959h

Cited by 11 publications

(6 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, we have focused on afterglow zirconia (ZrO 2 ) as a sensing probe. ZrO 2 is an accessible material and possesses a high chemical-stability and bio-compatibility 10 . In addition, the size, morphology, physical and optical properties can be controlled by choice of appropriate synthetic conditions and dopants 11,12 .…”

Section: Conception and Fundamental Principle Of Temperature Measurementmentioning

confidence: 99%

Temperature dependence of afterglow in zirconia and its optically-stimulated luminescence by bone-through irradiation for biological temperature probe

Ohashi

Takahashi

Terakado

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Development of minimally invasive and site-selective biological temperature sensing is quite importantin medical field. This study presents a novel temperature sensing technique based on afterglow and optically-stimulated luminescence (OSL). The dependence of afterglow photoluminescent intensity on the environmental temperature of zirconia (Zro 2 ) phosphor is examined to validate its use as a sensing probe. In addition, assuming the measurement in deep-part of human body, we have applied the information gathered from our validation to observe oSL from the Zro 2 by irradiation with near-infrared laser through a bone sample. This study demonstrates an alternative medical application of phosphor, and introduces an elemental-technology for the temperature sensing.Body temperature is main vital sign, which is closely related to immune system and metabolism. A technique for biological temperature monitoring is a powerful tool for medical treatment and monitoring human health. In addition, targeted temperature management has the potential to reduce the risk of brain dysfunction after a head injury and cardiopulmonary arrest. Although clinical thermometers and thermography are non-invasive, the methods measure the temperature on the surface of body. The gold standard for measuring temperature in critically ill patients is the Swan-Ganz catheter (Suppl. Fig. S1). The catheter must be inserted into the body in order to monitor the temperature at the desired location. Consequently, there is a need for accessible and minimally invasive temperature sensing methods which can monitor local internal temperature.Optical/spectroscopic measurement is recognized to be a minimally invasive and contactless method, and particularly, fluorescent and afterglow phenomena have been attempted to utilize for sensing-/imaging-applications so far 1-5 . Quantum-dots and fluorescent polymers have been proposed as temperature sensors for cell-imaging due to the relationship between temperature and fluorescence intensity/lifetime 1,2 . The observation of these effects is only possible with the magnification of a microscope. Chermont et al. developed a bio-imaging technique using afterglow phosphor of Eu 2+ , Dy 3+ , Mn 2+ -tri-doped Ca 0.2 Zn 0.9 Mg 0.9 Si 2 O 6 6 . Their study results inspired us to use the afterglow phenomenon to measure the temperature within the human body. In this manuscript, the fundamental measurements necessary to validate the use of the decay curve in the afterglow phosphor to measure temperature are presented. In addition, optically-stimulated luminescence (OSL) phenomena was also considered as irradiation of near-infrared (NIR) laser light would enable site-selective photoluminescence (PL), making it possible to obtain temperature information at internal sites in the human body.www.nature.com/scientificreports www.nature.com/scientificreports/ line. This departure was probably due to a partial electron-release from a deeper-trapping site corresponding to the peak F with peak at ~353 K. The pre-heating process is an eff...

show abstract

Section: Conception and Fundamental Principle Of Temperature Measurementmentioning

confidence: 99%

Temperature dependence of afterglow in zirconia and its optically-stimulated luminescence by bone-through irradiation for biological temperature probe

Ohashi

Takahashi

Terakado

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Besides, the shift in surface plasmon band Au, the absorption band of ZrO 2 also red-shifted from 280 nm to 320 nm. This could be due to surface defects created by the binding of Au NPs on the surface of the ZrO 2 NPs [26].…”

Section: Resultsmentioning

confidence: 99%

Facile Sonochemical Preparation of Au-ZrO2 Nanocatalyst for the Catalytic Reduction of 4-Nitrophenol

et al. 2020

Self Cite

View full text Add to dashboard Cite

High-intensity ultrasonic waves have great potential for the green synthesis of various nanomaterials under mild conditions and offer an excellent alternative for hazardous chemical methods. Herein a facile approach for the eco-friendly synthesis of Au-ZrO2 nanocatalyst with a high catalytic activity using a facile ultrasonic method is presented. Gold (Au) in the nanosize regime was successfully deposited on the surface of solvothermally synthesized monodispersed ZrO2 nanoparticles (ZrO2 NPs) in a very short period of time (5 min) at room temperature. Spherical shape small size Au nanoparticles that are uniformly dispersed on the surface of ZrO2 nanoparticles were obtained. Notably, in the absence of ZrO2 nanoparticles, HAuCl4 could not be reduced, indicating that nano-sized ZrO2 not only acted as support but also helped to reduce the gold precursor at the surface. The as-prepared Au-ZrO2 nanocatalyst was characterized by various techniques. The Au-ZrO2 nanocatalyst served as a highly efficient reducing catalyst for the reduction of 4-nitrophenol. The reaction time decreased with increasing the amount of catalyst.

show abstract

“…occurrence [33]. The oxygen vacancy in the ZnO NPs hexagonal wurtzite structure and its crystallinity shape made the defects possible [33,34].…”

Section: Zinc Oxide Nanoparticle Characteristicsmentioning

confidence: 99%

“…The O-H bending represents a phenolic stretch group [37]. The aliphatic hydrocarbons stretching [38] or of aldehydes [34] were indicated by C-H bending. The C=C bending represents the aromatic ring stretching and the C-N is from the aliphatic amines [39].…”

Section: Zinc Oxide Nanoparticle Characteristicsmentioning

confidence: 99%

Removal of Free Cyanide by a Green Photocatalyst ZnO Nanoparticle Synthesized viaEucalyptus globulusLeaves

Razanamahandry

Sackey

Saqib

et al. 2020

Photocatalysts in Advanced Oxidation Processes for Wastewater Treatment

View full text Add to dashboard Cite

Free Cyanide (FCN) is a harmful product released into the environment by several metallurgical industries. Various concentrations of Zinc Oxide (ZnO) nanoparticles have been synthesized by green method using Eucalyptus globulus leaves and tested for FCN removal. The optical and physico-chemical characteristics of the synthesized ZnO nanoparticles were investigated. X-ray diffraction has shown a pure crystallite Zincite form with average size 9.8 nm. Their bandgaps were obtained by UV-VIS

show abstract

Amine functionalized ZrO₂nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging

Abstract: Surface functionalized ZrO2 nanoparticles show strong photoluminescence and are a versatile tool for cellular targeting due to their chemical functionality.

Cited by 11 publications

References 52 publications

Temperature dependence of afterglow in zirconia and its optically-stimulated luminescence by bone-through irradiation for biological temperature probe

Temperature dependence of afterglow in zirconia and its optically-stimulated luminescence by bone-through irradiation for biological temperature probe

Facile Sonochemical Preparation of Au-ZrO2 Nanocatalyst for the Catalytic Reduction of 4-Nitrophenol

Removal of Free Cyanide by a Green Photocatalyst ZnO Nanoparticle Synthesized viaEucalyptus globulusLeaves

Contact Info

Product

Resources

About

Amine functionalized ZrO2nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging

Abstract: Surface functionalized ZrO2 nanoparticles show strong photoluminescence and are a versatile tool for cellular targeting due to their chemical functionality.

Cited by 11 publications

References 52 publications

Temperature dependence of afterglow in zirconia and its optically-stimulated luminescence by bone-through irradiation for biological temperature probe

Temperature dependence of afterglow in zirconia and its optically-stimulated luminescence by bone-through irradiation for biological temperature probe

Facile Sonochemical Preparation of Au-ZrO2 Nanocatalyst for the Catalytic Reduction of 4-Nitrophenol

Removal of Free Cyanide by a Green Photocatalyst ZnO Nanoparticle Synthesized viaEucalyptus globulusLeaves

Contact Info

Product

Resources

About

Amine functionalized ZrO₂nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging