Amine accumulation in Parkinson's disease and other disorders

Willis, Gregory L.

doi:10.1016/s0149-7634(87)80004-0

Cited by 12 publications

(4 citation statements)

References 95 publications

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“…Also, accumulation of amines (which could secondarily lead to increased formation of monoamine modified-a,M) has been often observed in the axons of degenerating, amine-containing neurons, and it is a natural component of neuronal death in many animal species. Increased levels of amines have also been detected in cerebral infarction, Parkinson's disease, Alzheimer's disease, and Huntington's cholera (Willis, 1987). We learn from this study that aZM, once activated by biogenic monoamines, can produce inhibitory effects on NGF-responsive sensory neurons and certain CNS neurons, perhaps via its interference with the neurotrophin action.…”

Section: Discussionmentioning

confidence: 70%

Serotonin‐activated α₂‐macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons

Liebl

Koo

1993

J of Neuroscience Research

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Methylamine-modified alpha-2-macroglobulin (MA-alpha 2M) has been recently shown to inhibit the biological activity of beta-nerve growth factor (NGF) in promoting neurite outgrowth by embryonic dorsal root ganglia in culture (Koo PH, Liebl DJ, J Neurosci Res 31:678-692, 1992). The objectives of this study are to determine whether alpha 2M can also be modified by larger aromatic biogenic amines such as 5-hydroxytryptamine (5HT; serotonin), the nature of interaction between NGF and 5HT-modified alpha-2-M (5HT-alpha 2M), and the effect of 5HT-alpha 2M on the neurite extension and the growth of embryonic sensory and cholinergic neurons in 2 disparate animal species (chicken and rats). This study demonstrates that each mole of alpha 2M can combine with 15.2 +/- 1.8 moles of 5HT, in which up to 4.5 +/- 0.4 moles may be covalently bonded. As determined by gel filtration and polyacrylamide gel electrophoresis studies, both 5HT-alpha 2M and normal alpha 2M combine noncovalently with NGF, but 5HT-alpha 2M by comparison can combine with NGF somewhat more effectively. In contrast to normal alpha 2M, 5HT-alpha 2M at concentrations greater than about 0.17 microM exerts a dose-dependent inhibition on the NGF-stimulated neurite outgrowth by embryonic dorsal root ganglia and dissociated cells in culture, and the inhibitory effect can be overcome by higher NGF concentrations. Both 5HT-alpha 2M and MA-alpha 2M at 1.0 microM inhibit neurite extension by embryonic rat cerebral cortical cells and seriously damage these cells in culture. Such neurite-inhibitory activity, however, can only be partially blocked by extraneously added NGF alone. Normal alpha 2M (at 1.0 microM) and 5HT (at 188 microM), on the other hand, under the identical conditions produce very little or no effect on the normal cellular and axonal growth of these cells. We conclude that alpha 2M can potentially interact with nucleophilic monoamines, including neurotransmitters, to form inhibitory complexes which may inhibit/regulate NGF-promoted neurite outgrowth and neuronal survival. In addition, higher concentrations of such complexes can seriously damage certain CNS neurons which do not depend solely on NGF for survival.

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Section: Discussionmentioning

confidence: 70%

Serotonin‐activated α₂‐macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons

Liebl

Koo

1993

J of Neuroscience Research

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“…The DA is an inhibitor neurotransmitter, involved in the control of movement and posture and in various neurological or psychiatric diseases such as Parkinson's disease (Willis 1987) and schizophrenia (Wolf et al 1993). 5-HT plays an important role in different physiological functions, such as sleep, food intake, circadian rhythm, cognitive functions, pain, and brain development (Fuller 1992), and it is involved in several psychiatric disorders: depression, suicide, impulsive behaviour, and aggressiveness (Fuller 1992).…”

Section: Discussionmentioning

confidence: 99%

Effect of U and ¹³⁷Cs chronic contamination on dopamine and serotonin metabolism in the central nervous system of the rat

Houpert

Lestaevel²,

Amourette³

et al. 2004

Can. J. Physiol. Pharmacol.

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Following the Chernobyl accident, the most significant problem for the population of the former Soviet Union for the next 50-70 years will be chronic internal contamination by radionuclides. One of the few experiments carried out in this field reported that neurotransmitter metabolism in the central nervous system of the rat was disturbed after feeding with oats contaminated by 137Cs for 1 month. The present study assessed the effect of chronic contamination by depleted U or 137Cs on the metabolism of two neurotransmitters in cerebral areas of rats. Dopamine and serotonin were chosen because their metabolism has been shown to be disturbed after external irradiation, even at moderate doses. Dopamine, serotonin, and some of their catabolites were measured by high-pressure liquid chromatography coupled with an electrochemical detector in five cerebral structures of rats contaminated over a 1-month period by drinking water (40 mg U.L -1 or 6500 Bq 137Cs.L -1). In the striatum, hippocampus, cerebral cortex, thalamus, and cerebellum, the dopamine, serotonin, and catabolite levels were not significantly different between the control rats and rats contaminated by U or 137Cs. These results are not in accordance with those previously described.

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“…Activated or ''fast'' ␣ 2 M has been detected to occur normally in various biologic fluids and its concentration is greatly increased in several human inflammatory conditions investigated (Jespersen et al, 1993;Bank et al, 1990Bank et al, , 1991. In addition, accumulation of amines has been detected in cerebral infarction, Parkinson's disease, Alzheimer's disease, and Huntington Chorea, as well as in the axons of degenerating neuros (Willis et al, 1987). The conditions under which activated ␣ 2 M can accumulate in the brain have been discussed .…”

Section: Discussionmentioning

confidence: 99%

Inhibition of dopamine and choline acetyltransferase concentrations in rat CNS neurons by rat ?1- and ?2-macroglobulins

Liebl

Dluzen

et al. 1998

J. Neurosci. Res.

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Previous studies have implicated human alpha-2-macroglobulin (alpha2M) as a potential regulator of neuronal development and function. Rat alpha-1-macroglobulin (alpha1M) and acute-phase alpha-2-macroglobulin (alpha2M) are murine homologues of human alpha2M. In this report, we tested the effect of intracranially infused serotonin-activated rat alpha1M (5HT-alpha1M) on the concentration of dopamine (DA) in the corpus striatum in vivo and the effect of 5HT-activated rat alpha1M and alpha2M on the choline acetyltransferase (ChAT) activity upon embryonic basal forebrain neurons in culture. The results show that direct infusion of 0.65 nmole rat 5HT-alpha1M into the adult rat corpus striatum produced a consistent attenuation upon striatal DA concentrations. This decrease was particularly prominent at 5-7 days post-infusion. In addition, rat 5HT-alpha1M and rat 5HT-alpha2M, like human 5HT-alpha2M, all significantly inhibited ChAT activity of embryonic rat cerebral cortex neurons. Although normal human alpha2M and rat alpha2M were either marginally or insignificantly inhibitory in this preparation, normal rat alpha1M dose-dependently inhibited ChAT activity. These results demonstrate that monoamine-activated alpha-macroglobulins from rat depress dopaminergic and cholinergic neurotransmitter systems in the CNS, and this suggests a potential regulatory role of these alpha-macroglobulins in neurotransmitter metabolism.

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Amine accumulation in Parkinson's disease and other disorders

Cited by 12 publications

References 95 publications

Serotonin‐activated α₂‐macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons

Serotonin‐activated α₂‐macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons

Effect of U and ¹³⁷Cs chronic contamination on dopamine and serotonin metabolism in the central nervous system of the rat

Inhibition of dopamine and choline acetyltransferase concentrations in rat CNS neurons by rat ?1- and ?2-macroglobulins

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Amine accumulation in Parkinson's disease and other disorders

Cited by 12 publications

References 95 publications

Serotonin‐activated α2‐macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons

Serotonin‐activated α2‐macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons

Effect of U and 137Cs chronic contamination on dopamine and serotonin metabolism in the central nervous system of the rat

Inhibition of dopamine and choline acetyltransferase concentrations in rat CNS neurons by rat ?1- and ?2-macroglobulins

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Product

Resources

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Serotonin‐activated α₂‐macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons

Serotonin‐activated α₂‐macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons

Effect of U and ¹³⁷Cs chronic contamination on dopamine and serotonin metabolism in the central nervous system of the rat