Amiloride and calciuria

Luft, Friedrich C.; Sällström, Johan

doi:10.1093/ndt/gfab221

Cited by 1 publication

(3 citation statements)

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“…Moreover, it has demonstrated clear benefits in preventing and treating coronary events and strokes. The effectiveness of amiloride in resistant hypertension has been shown in recent years, but its potential role in mild to moderate hypertension has not yet been established [21]. A 5mg, 10, 20, 30, 40, and 60mg oral tablet is recommended for adults, and it should be administered with food or meals to prevent gastrointestinal upset [20].…”

Section: Amiloridementioning

confidence: 99%

“…The onset of action of this drug occurs within 2-3 hours, with a peak effect occurring between 6-10 hours after administration and a duration of approximately 24 hours. Absorption ranges from 30% to 90% and can be reduced to 30% when co-administered with food [21].…”

Section: Amiloridementioning

confidence: 99%

“…Furthermore, patients with cirrhosis may suffer from imbalances in acid/base, which can result in hepatic encephalopathy. As the kidneys eliminate this drug, patients with renal impairment may be at greater risk of experiencing amiloride-related side effects [20,21].…”

Section: Amiloridementioning

confidence: 99%

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Management of Nephrogenic Diabetes Insipidus: An Overview

Coral

2022

JOJUN

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Diabetes insipidus is a disorder in which the collecting tubules are impermeable to water provoking the excretion of large amounts of diluted urine. In central diabetes insipidus, the release of antidiuretic hormone is decreased, while in nephrogenic diabetes insipidus, the response of the kidneys to this hormone is defective. Common clinical manifestations include polyuria, nocturia, and polydipsia. Laboratory findings show electrolytic imbalance, particularly hypernatremia. Diagnosis can be determined by a hypertonic saline infusion and water deprivation test. In addition to a thorough medical history and physical examination, lab tests and imaging procedures are commonly required. Treatment strategies include diet restrictions, hydration, thiazide diuretics, indomethacin, chlorthalidone, amiloride, and desmopressin. The management of this disorder is facilitated by combining various therapies and considering contraindications to each treatment. However, further studies are necessary to develop safer and more effective medications to manage this complex condition.

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Section: Amiloridementioning

confidence: 99%

Section: Amiloridementioning

confidence: 99%