Amiloidosis AA en paciente infectado por el virus de la inmunodeficiencia humana: comunicación de un caso y revisión de la literatura

Navarro, J. M. de; Díaz, C. Caramelo; Marrón, Belén; Barat, A.; Praga, Manuel; Riñón, C

doi:10.1016/s0014-2565(03)71197-7

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…The exact mechanism of amyloidosis in HIV is unknown. However, reduced IL-2 levels during HIV infection may result in the generation of pro-inflammatory cytokines which might cause the production of these abnormal proteins [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Nephrotic Syndrome in a Retroviral Disease Due to AA Amyloidosis: A Rare Presentation

Kashiv,

Dubey,

Sejpal

et al. 2023

Cureus

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Kidney disease poses a significant burden on individuals with HIV infection. In the pre-ART era, HIV-associated nephropathy (HIVAN) was the most common renal pathology identified in individuals with HIV. However, the widespread use of ART has led to changes in the spectrum of renal pathologies associated with HIV. HIV infection is an unclear cause of AA amyloidosis. Here, we report a rare case of an HIV-positive patient presenting with nephrotic syndrome which turned out to be AA amyloidosis on renal biopsy.

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Section: Discussionmentioning

confidence: 99%

Nephrotic Syndrome in a Retroviral Disease Due to AA Amyloidosis: A Rare Presentation

Kashiv,

Dubey,

Sejpal

et al. 2023

Cureus

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Amiloidosis intestinal en paciente con infección por VIH

Segoviano-Mateo

Rojano-Martín

Díaz-Ley

et al. 2005

Enfermedades Infecciosas y Microbiología Clínica

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AA Amyloidosis in the Course of HIV Infection: A Report of 19 Cases Including 4 New French Cases and a Comprehensive Review of Literature

Breillat

Pourcher

Deshayes

et al. 2021

Nephron

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Introduction: HIV infection has been recently retained as an unclear cause of AA amyloidosis. Our aim was to investigate cases of AA amyloidosis associated with HIV infection to understand if it could be considered as a cause of AA amyloidosis. Methods: A comprehensive literature review was conducted as well as retrospective study from French cases collected from our national reference center for AA amyloidosis. Results: Altogether, 19 patients with AA amyloidosis and HIV infection were found with 68% of men and median age at amyloidosis diagnosis of 38 years (range 28–75 years). Clinical presentation was nephrotic syndrome in 94% (n = 17/18). Among patients with renal involvement and assessable outcome (n = 17), 11 (64.7%) progressed to chronic kidney disease, with 6 (35%) end-stage renal disease. Seventy-five percent of patients had uncontrolled HIV infection and 71.4% CD4 counts <400/mm3 at amyloidosis diagnosis. Repeated or chronic bacterial or fungal infection was found in 47% of cases and a history of parenteral drug use in 55% of patients. Three patients had no classical or at least no suspected AA amyloidosis cause found or reported. Conclusions: AA Amyloidosis is a rare condition in HIV patients with common renal involvement and significant risk of progression to chronic renal insufficiency. Because of the frequency related to other inflammatory conditions in this population, HIV is probably not an independent risk factor for AA amyloidosis.

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Amiloidosis AA en paciente infectado por el virus de la inmunodeficiencia humana: comunicación de un caso y revisión de la literatura

Cited by 4 publications

References 7 publications

Nephrotic Syndrome in a Retroviral Disease Due to AA Amyloidosis: A Rare Presentation

Nephrotic Syndrome in a Retroviral Disease Due to AA Amyloidosis: A Rare Presentation

Amiloidosis intestinal en paciente con infección por VIH

AA Amyloidosis in the Course of HIV Infection: A Report of 19 Cases Including 4 New French Cases and a Comprehensive Review of Literature

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