Amikacin Sulfate

Monteleone, Peter M.; Naseem, Muhammad; Brown, Robert D.; McGrory, John P.; Hanna, Samir Abdallah

doi:10.1016/s0099-5428(08)60163-x

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…Cations, which are generally more hydrated than anions, have a greater tendency to remain in the bulk aqueous phase compared with the large, more polarizing and less hydrated anions which consequently are adsorbed more easily. Given that AKS is Positively charged (pKa = 8.1) at the pH of the incubation medium (pH = 7.4) (Monteleone et al 1983) and that the drug adsorption process induced a reduction of a zeta potential of the particles, it can be assumed that AKS was adsorbed onto the particles essentially by a mechanism of electrostatic interaction between drug and adsorbent polymer particles. Moreover, this mechanism explains the lower adsorption capacity of Synperonic stabilized nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

Improvement of Ocular Penetration of Amikacin Sulphate by Association to Poly(butylcyanoacrylate) Nanoparticles

Losa

Calvo

Castro

et al. 1991

Journal of Pharmacy and Pharmacology

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The main objective of this paper was to investigate the ability of polycyanoacrylate nanoparticles to improve the corneal penetration of hydrophilic drugs. Three different nanoparticle formulations were prepared by changing the nature of the stabilizer agent (Dextran 70000, Synperonic F 68 and sodium lauryl sulphate). The significant influence of the stabilizer type on the particle size, electrophoretic mobility and on the drug loading efficiency was proved. Moreover, the ocular disposition of amikacin was affected by its association to nanoparticles, displaying the most interesting results when Dextran 70000 was employed for preparation of nanoparticles. The increase of the amikacin concentration in cornea and aqueous humour was statistically significant for this nanoparticle formulation with respect to the other formulations and the control solution. The in-vitro release profiles obtained using a dialysis system were similar for all the nanoparticle formulations and for the control solution, indicating that drug molecules are desorbed from the nanoparticles quickly enough to maintain the equilibrium concentration in the dialysis system.

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Section: Resultsmentioning

confidence: 99%

Improvement of Ocular Penetration of Amikacin Sulphate by Association to Poly(butylcyanoacrylate) Nanoparticles

Losa

Calvo

Castro

et al. 1991

Journal of Pharmacy and Pharmacology

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“…Amikacin, an aminocyclitol antibiotic, possesses weak UV absorption characteristics, limiting its quantitative analysis through spectrophotometry [5]. Thus, developing a suitable chromogenic system becomes imperative to enable sensitive UV/VIS detection of amikacin in bulk and dosage forms.…”

Section: Principle Of the Analytical Methodsmentioning

confidence: 99%

“…The method analyzed drug content in amikacin injections, giving 100.76±1.2% and 100.6±1.96% (n=3) at 390nm and 540nm. We recognized the need to develop new methods to analyze amikacin purity and potency [5]. Though several techniques had been proposed, none employed visible spectrophotometry using ascorbic acid reagent -an approach we believed could provide useful complementary information.…”

Section: Application Of the Developed Methodsmentioning

confidence: 99%

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Novel colorimetric approach for amikacin estimation in pure powder and its pharmaceutical formulations

Mangam¹,

Sarella²,

Siddhantapu³

et al. 2023

World J. Bio. Pharm. Health Sci.

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A sensitive and validated colorimetric method was developed and optimized for the estimation of amikacin sulfate in pure and pharmaceutical dosage forms. Ascorbic acid was used as a chromogenic reagent to produce a stable color complex with amikacin that absorbs strongly at 390nm and 540nm. Several experimental factors were evaluated to maximize color development and stability, including solvent, reagent concentration, reaction time, and temperature. Optimal conditions were found using DMSO solvent, 0.2% ascorbic acid, and 40 minutes reaction time at 25°C. Under these conditions, Beer's law was obeyed in the range of 40-200μg/mL with high correlation coefficients, indicating excellent linearity. The method was validated in terms of linearity, accuracy, precision, detection/quantitation limits, and application to actual samples as per ICH guidelines. Recovery studies showed nearly 101% accuracy. Low relative standard deviations reflected high precision. Limits of detection/quantitation were 19-57μg/mL, enabling reliable analysis even at low concentrations. The method quantified amikacin content in injections, giving 98-102% accuracy. Statistical comparisons to a validated method gave no significant differences, confirming this approach provides equivalent results.

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Aggregation and Adsorption Behavior of Cationic Surfactants (Cetyltrimethylammonium Bromide and Dodecyltrimethylammonium Bromide) in Aqueous Solutions of Antibiotic Drug (Amikacin Sulphate) at Different Temperatures

Chauhan

Chaudhary

Sharma³

2020

J Surfact & Detergents

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Conductivity and spectroscopy techniques have been accomplished to comprehend the mechanism of supramolecular assembly of cetyltrimethylammonium bromide (CTAB) and dodecyltrimethylammonium bromide (DTAB) in aqueous solution of amikacin sulphate (0.001, 0.005, and 0.010 mol kg −1). For CTAB, the normal boost of the CMC value with rise in temperature manifests the significant role of aquaphilic dehydration. However, the aquaphobic dehydrations become prominent with temperature and depict typical U-shaped behavior of CMC for DTAB. The thermodynamic parameters of micellization have been derived from CMC values. The outcomes have been conferred in terms of solvation of hydrophobic part of surfactants by hydrophobic part of amikacin sulphate and micellization becomes more favorable for surfactant with more hydrophobic character in the presence of drug. The alteration in micro-environment of the ternary (drug/surfactant/water) system has been explained in terms of fluorescence emission intensity of surfactant solutions which has been found to decrease by the addition of drug. The obtained absorbance spectrum by varying concentrations of surfactant/drug affords noteworthy information regarding the diverse interactions in studied systems. Moreover, the exhaustive understanding of surfactant micellar behavior have been discussed in consideration of use of surfactants as drug delivery agents and hence to amplify drug bioavailability consequently remodeling its treatment efficacy.

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Amikacin Sulfate

Cited by 7 publications

References 25 publications

Improvement of Ocular Penetration of Amikacin Sulphate by Association to Poly(butylcyanoacrylate) Nanoparticles

Improvement of Ocular Penetration of Amikacin Sulphate by Association to Poly(butylcyanoacrylate) Nanoparticles

Novel colorimetric approach for amikacin estimation in pure powder and its pharmaceutical formulations

Aggregation and Adsorption Behavior of Cationic Surfactants (Cetyltrimethylammonium Bromide and Dodecyltrimethylammonium Bromide) in Aqueous Solutions of Antibiotic Drug (Amikacin Sulphate) at Different Temperatures

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