AMIJIOL, ISOAMIJIOL, AND 14-DEOXYAMIJIOL, THREE NEW DITERPENOIDS FROM THE BROWN SEAWEED DICTYOTA LINEARIS

Abstract

Three new diterpenoids have been isolated from the brown seaweed Dictyota linearis, and their structures determined by 1H and 13C NMR spectroscopy.

Inhibition of mammal Na+K+‐ATPase by diterpenes extracted from the Brazilian brown alga Dictyota cervicornis

“…The dolastane diterpenes (1) and (2) are known compounds previously isolated from D. divaricata and D. linearis (Sun et al, 1981;Crew et al, 1982) and an unidentified Dictyota from the Canary Islands (Gonzalez et al, 1983). Several of these diterpenoids showed antimicrobial activity against Bacillus subtilis and Penicillium crustosum (Ochi et al, 1980), Staphylococcus aureus and Mucor mucedo (Ochi et al, 1986) and as cytotoxic compounds (Crew et al, 1982). Although some diterpenes have been isolated from Dictyota spp., it was shown that two of them are inhibitors of Na + K + -ATPase.…”

A Clade II‐D Fungal Chimeric Diterpene Synthase from Colletotrichum gloeosporioides Produces Dolasta‐1(15),8‐diene

“…Amijiol (4), 14-deoxyamijiol (5), and isoamijiol (6)a re also known from brown algae. [26] Notably,t he algal compounds exhibit a5,14-di-epi skeleton compared to fungal 1.NoTSfor dolastane diterpenes has been reported so far,w hile the intermediate d-araneosene was observed as aside product of (+ +)-fusicocca-2,10(14)-diene synthase from P. amygdali. [7] Access to dolastanes is of high interest because several oxidized members of this class modulate the effects of other drugs in resistant S. aureus strains.…”

Eine chimäre pilzliche Diterpensynthase der Klade II‐D aus Colletotrichum gloeosporioides produziert Dolasta‐1(15),8‐dien

“…Weiterhin sind Amijiol (4), 14-Deoxyamijiol (5) und Isoamijiol (6)a us Braunalgen bekannt. [26] Bemerkens-Schema 2. A) Cyclisierungsmechanismus fürCgDS.…”