Amifostine—Antioxidant Drug in Anticancer Therapy

Stankiewicz, Anna; Skrzydlewska, Elżbieta

doi:10.1080/15376520500195608

Cited by 6 publications

(4 citation statements)

References 55 publications

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“…Many common clinical drugs have been used as potent acrolein-sequestering agents, which includes thiol-containing and hydrazine-containing substances [80]. Drugs with thiol groups, such as amifostine, mesna, N-acetylcysteine (NAC) and cysteamine [81,82], show considerable acrolein sequestering activity. Amifostine can be metabolised by alkaline phosphatase to release active WR-1065.…”

Section: Interactions Of Acrolein With Clinical Drugsmentioning

confidence: 99%

Origin and Fate of Acrolein in Foods

Jiang

Huang

Liu

et al. 2022

Foods

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Acrolein is a highly toxic agent that may promote the occurrence and development of various diseases. Acrolein is pervasive in all kinds of foods, and dietary intake is one of the main routes of human exposure to acrolein. Considering that acrolein is substantially eliminated after its formation during food processing and re-exposed in the human body after ingestion and metabolism, the origin and fate of acrolein must be traced in food. Focusing on molecular mechanisms, this review introduces the formation of acrolein in food and summarises both in vitro and in vivo fates of acrolein based on its interactions with small molecules and biomacromolecules. Future investigation of acrolein from different perspectives is also discussed.

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Section: Interactions Of Acrolein With Clinical Drugsmentioning

confidence: 99%

Origin and Fate of Acrolein in Foods

Jiang

Huang

Liu

et al. 2022

Foods

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“…apoptosis) (Jacob et al 2006;Ramaiah and Jaeschke 2007;Singh et al 2007;Sharifi and Mousavi 2008). These apoptosis-related proteins also play crucial roles in inducing apoptosis of cancer cells in cancer chemotherapy (Wang and El-Deiry 2004;Stankiewicz and Skrzydlewska 2006).…”

Section: Introductionmentioning

confidence: 98%

CAS Enhances Chemotherapeutic Drug-Induced p53 Accumulation and Apoptosis: Use of CAS for High-Sensitivity Anticancer Drug Screening

Liao

Luo

Tsai

et al. 2008

Toxicology Mechanisms and Methods

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Cells attacked by cytotoxic toxins may express apoptosis-related proteins such as p53 to kill themselves, so as not to affect surrounding healthy cells. These apoptosis-related proteins are also crucial for inducing apoptosis of tumor cells in cancer chemotherapy. CSE1L/CAS is a cellular apoptosis susceptibility protein that plays important roles in mediating cell apoptosis induced by various cytotoxic toxins and chemotherapeutic drugs. Our studies showed that CAS over-expression increased p53 accumulation and apoptosis induced by 5-fluorouracil, doxorubicin, cisplatin, and tamoxifen in HT-29 cancer cells. A method based on coexpression of CAS with green fluorescence protein (GFP) was developed for high-sensitivity anticancer drug screening. Cancer cells transfected with CAS- and GFP-expressing vectors or the control and GFP-expressing vectors were grown on 96-well microplates, treated with compounds to be screened, and detected with a microplate fluorescence reader. GFP fluorescence decreased following cancer cell death induced by the anticancer compounds. CAS transfection enhanced the cytotoxicities of anticancer compounds and therefore increased the decline in GFP fluorescence. Thus, anticancer compounds could be identified more sensitively. Our study indicates that CAS is an important p53 and apoptosis regulator and may be used for high-throughput anticancer drug screening as well as cytotoxic toxin assays.

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“…One novel cytoprotective method used in anticancer therapy is the combination of cytostatic delivery together with an antioxidant agent, which may be a potential therapeutic approach to reversing or arresting the progress of CP adverse effects [47][48][49][50]. For a long time, many reports have pointed to the important role of ascorbic acid in the prevention and treatment of cancer.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, CP metabolism is probably different in bacteria cells in comparison to human cells. Maybe, as a result of CP biochemical changes, other intermediate metabolites are formed, which can also generate free radical production [47][48][49][50]57].…”

Section: Antimicrobial Activity Studymentioning

confidence: 99%

Using an <i>Escherichia Coli</i> K-12/<i>recA-gfpmut2</i> Microbial Biosensor to Assess the Impact of Cyclophosphamide and L-ascorbic Acid Residues on Living Bacteria Cells

Matejczyk¹,

Świsłocka²,

Lewandowski³

2020

Pol. J. Environ. Stud.

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Pharmaceutical residues and their transformation products (TPs) have been found in wastewaters and aquatic environments, and they cause adverse effects in aquatic organisms, especially upon chronic exposure and even at very low doses. Cyclophosphamide (CP) is a common alkylating agent that is effective against a wide variety of tumors. L-ascorbic acid is a known water-soluble vitamin that has antioxidant properties. The pharmaceutical residues of both drugs are detected in the environment, and as biologically active molecules they have the ability to affect organisms. In this work we presented the use of a microbiological biosensor E. coli K-12/recA-gfpmut2 in the assessment of the effects of residues of cyclophosphamide and vitamin C and their mixtures on living cells. In our studies, we have shown that mixtures of CP and vitamin C in the highest CP concentrations are more toxic to E. coli strain compared to parent chemicals. In addition, we also found that drug mixtures, especially at the highest CP concentrations, more strongly stimulate the recA promoter and gfp gene expression. We showed that an Escherichia coli K-12/recA-gfpmut2 microbial biosensor is a useful tool in assessing the impact of pharmaceutical residues of cyclophosphamide and L-ascorbic acid and their mixture on living bacteria cells. A stronger impact and toxicity of the mixtures of both tested chemical compounds was found in comparison to parent chemicals.

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Amifostine—Antioxidant Drug in Anticancer Therapy

Cited by 6 publications

References 55 publications

Origin and Fate of Acrolein in Foods

Origin and Fate of Acrolein in Foods

CAS Enhances Chemotherapeutic Drug-Induced p53 Accumulation and Apoptosis: Use of CAS for High-Sensitivity Anticancer Drug Screening

Using an <i>Escherichia Coli</i> K-12/<i>recA-gfpmut2</i> Microbial Biosensor to Assess the Impact of Cyclophosphamide and L-ascorbic Acid Residues on Living Bacteria Cells

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