Amidrazones in the synthesis of heterocycles (review)

1,2,4-Triazine Sulfonamides: Synthesis by Sulfenamide Intermediates, In Vitro Anticancer Screening, Structural Characterization, and Molecular Docking Study

“…The synthesis of 1,2,4-triazine sulfonamide derivatives was started from 3-amino-1,2,4-triazine 1. The synthesis involved a condensation reaction between acetamidrazone with glyoxal [21]. First, amino-1,2,4-triazine was reacted with p-nitrobenzene sulfenyl chloride (2a), which led to the formation of sulfenamide 3a in a yield of 46%.…”

“…MCF-7 cells were seeded in six-well plates and were incubated with varying concentrations of 1-18 or chlorambucil and 0.5 µCi of [ 3 H]-thymidine for 24 h at 37 • C [21]. The cells were then harvested by trypsinization, washed with cold phosphate-buffered saline, and centrifuged for 10 min at 1500× g times (4-5) until the dpm in the washes were similar to the reagent control.…”

One‐Pot Reaction of Amidrazones, Phthaloyl Chloride, and Triethyl Amine: Synthesis of 1‐(1′,2′,4′‐Triazole)‐2‐Benzoic Acid

“…They were also found to be effective herbicides , pesticides , and insecticides . The interest in amidrazones and their derivatives is not only for their biological relevance but also for their applications as precursors in the synthesis of many heterocyclic compounds . Aly et al have a long‐running program of synthesis of various heterocycles from amidrazones such as pyrazoles , pyrimidinethiols , 1,2,4‐triazepine‐6,11‐diones , triazoles , and triazolium salts .…”

Reaction of Amidrazones with Diaminomaleonitrile: Synthesis of 4‐Amino‐5‐Iminopyrazoles

“…The interest in amidrazones and their derivatives stems not only from their biological relevance but also from their applications as precursors and intermediates for the synthesis of many heterocyclic compounds or as ligands in coordination chemistry. Amidrazones can also react with a wide range of transition metals in their neutral or ionic forms, and they show a diversity of coordination modes , which can lead to complexes having different geometries and various molecular arrangements.…”