Amidophenacylating reagents in synthesis of new derivatives of 1,3-oxazole- and 1,3-thiazole-4-sulfonyl chlorides and corresponding sulfonamides

Synthesis and Antitumor Activity of 5-Phenyl-1,3-thiazole-4-sulfonamide Derivatives

“…1-Substituted 2-[(2-phenyl-2-oxoethyl)amino]-2-oxoacetates 6-8 were obtained for the first time. Their spectral SYNTHESIS AND ANTITUMOR ACTIVITY characteristics fully correspond to the expected ones and agree with the data for the previously described N-(2-aryl-1-R-2-oxoethyl)carboxamides with similar structures [15,17].…”

“…This work is a continuation of our research on the synthesis of thiazole-4-sulfonamides [15] in order to search for effective anticancer agents, and is based on the idea of creating previously unknown sulfonyl hybrids of thiazolecarboxylic acids.…”

“…To implement this task, we used an approach developed by us earlier [15][16][17] based on the cyclization of N-(2oxo-2-arylethyl)amides under the action of 2,4-bis(4methoxyphenyl)-1,3,2,4-dithiadiphosphetan-2,4-dithione (Lawesson's reagent) and oxidative chlorination of benzylsulfanyl-1,3-thiazoles. Ethyl 2-[(1-hydroxy-2oxo-2-phenylethyl)amino]-2-oxoacetate 6 obtained by heating a mixture of reagents in tetrahydrofuran (Scheme 2).…”

Synthesis of novel phosphorylated peptidomimetics which contain ω-haloalkyl and ω-thiocyanoethyl residues

“…It is known that 1,3-oxazole derivatives are reactive compounds and can be converted to other fiveand six-membered rings. [1][2][3][4][5][6][7][8][9][10] In addition, 1,3-oxazoles are unstable in an acidic medium and are cleaved by a water molecule to form acyclic products. 11,12 In the case of 4-functionalized 5-amino-1,3-oxazoles, this leads to formation of compounds of peptide nature.…”

Пошук Та Синтез Противірусних Агентів Серед Похідних Азотистих Гетероциклів

“…Для синтезу 1,3-оксазолів 7 або тіазолів 9 із сульфоніламідною групою в положенні 4 азольного кільця було використано відповідні 4-сульфонілхлориди 6 або 8, утворені з відповідних амідофенацилюючих реагентів 5 [12] (схеми 3, 4).…”