Amidine-based molecularly imprinted polymers?new sensitive elements for chiral chemosensors

Abstract

Using the optical measurement technique reflectometric interference spectroscopy (RIfS), the interaction of molecularly imprinted polymers (imprinted with either (R, R)- or (S, S)-2,3-di- O-benzoyltartraric acid) with the corresponding templates and template antipodes were investigated. With these sensors chiral separation with a separation factor of 1.2 could be achieved whereas a reference polymer resulted in no separation. RIfS signals were of opposite sign for imprinted polymer layers containing phenylboronic acid binding site monomers.

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

“…Methyl red itself was imprinted in a study by Liang and co-workers 254 to examine what effect imprinting has on the pK a of an indicator. A different approach was adopted by Nopper et al 1346 -measurements via reflective interference spectroscopy permitted design of a molecularly imprinted chiral chemosensor.…”

A Look into the Future: Chiral Analysis Using Chemical Sensor Technology

“…Several investigations have established the use of molecularly imprinted polymers as chiral selectors for chemical sensors [44][45][46][47][48]. A molecular imprinted polymer (MIP) is simply a polymer that was formed in the presence of a molecule of interest.…”

Molecularly Imprinted Polymer Waveguides for Direct Optical Detection of Low‐Molecular‐Weight Analytes

“…Numerous label-free optical sensor platforms were combined with molecularly imprinted polymers (MIP) [ 1 ] for detection of chemical and biological analytes including those utilizing surface plasmon resonance (SPR), [ 2,3 ] dielectric optical waveguides, [ 4,5 ] refl ection interference spectroscopy (RIFS), [ 6,7 ] and diffractive structures. [8][9][10] These optical sensors rely on the measurement of refractive index variations that are associated with a capture of target molecules by MIP on the sensor surface.…”