Amide proton transfer weighted MRI in differential diagnosis of ovarian masses with cystic components: A preliminary study

Yu, Y.; Song, Xiaolei; Zeng, Zhen; Wang, Lixue; Zhang, Lei; Zhao, Huanying; Zheng, Zhuozhao

doi:10.1016/j.mri.2023.07.014

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…As a non-invasive MR imaging technique at the molecular level, APTw can reflect the metabolic and pathophysiological information of the lesion by measuring the quantitative parameter APT value [21,22]. Meanwhile, APTw signals can reflect protein and peptide content of tumor tissue [23], which increases with increased cell density, heterotypy, microvascular density (MVD), and microscopic necrosis of tumor tissue [24,25], resulting in increased APT values. In addition, the increase in PH of the tumor microenvironment caused by hypoxia also contributes to the increase in APT values [26].…”

Section: Discussionmentioning

confidence: 99%

Multimodal MRI for Estimating Her-2 Gene Expression in Endometrial Cancer

Li,

Tian,

et al. 2023

Bioengineering

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Purpose: To assess the value of multimodal MRI, including amide proton transfer-weighted imaging (APT), diffusion kurtosis imaging (DKI), and T2 mapping sequences for estimating human epidermal growth factor receptor-2 (Her-2) expression in patients with endometrial cancer (EC). Methods: A total of 54 patients with EC who underwent multimodal pelvic MRI followed by biopsy were retrospectively selected and divided into the Her-2 positive (n = 24) and Her-2 negative (n = 30) groups. Her-2 expression was confirmed by immunohistochemistry (IHC). Two observers measured APT, mean kurtosis (MK), mean diffusivity (MD), and T2 values for EC lesions. Results: The Her-2 (+) group showed higher APT values and lower MD and T2 values than the Her-2 (−) group (all p < 0.05); there was no significant difference in MK values (p > 0.05). The area under the receiver operating characteristic curve (AUC) of APT, MD, T2, APT + T2, APT + MD, T2 + MD, and APT + MD + T2 models to identify the two groups of cases were 0.824, 0.695, 0.721, 0.824, 0.858, 0.782, and 0.860, respectively, and the diagnostic efficacy after combined APT + MD + T2 value was significantly higher than those of MD and T2 values individually (p = 0.018, 0.028); the diagnostic efficacy of the combination of APT + T2 values was significantly higher than that of T2 values separately (p = 0.028). Weak negative correlations were observed between APT and T2 values (r = −0.365, p = 0.007), moderate negative correlations between APT and MD values (r = −0.560, p < 0.001), and weak positive correlations between MD and T2 values (r = 0.336, p = 0.013). The APT values were independent predictors for assessing Her-2 expression in EC patients. Conclusion: The APT, DKI, and T2 mapping sequences can be used to preoperatively assess the Her-2 expression in EC, which can contribute to more precise treatment for clinical preoperative.

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