Amhezole, A Novel Fungal Secondary Metabolite from<i>Aspergillus terreus</i>for Treatment of Microbial Mouth Infection

Awaad, Amani S.; AL-Mudhayyif, Hind A.; Al‐Othman, Monerah R.; Zain, Mohamed E.; El‐Meligy, Reham M.

doi:10.1002/ptr.5760

Cited by 18 publications

(12 citation statements)

References 37 publications

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“…On the other hand, the extracts of most fungal isolates showed moderate anticandidal activities against the most of the Candida species. The current results revealed an anticandidal activity of the fungi isolated from soil, similarly, a huge number of antibiotics produced by filamentous fungi have been reported (Awaad et al, 2017, Ullah et al, 2017, Zain et al, 2014).…”

Section: Resultssupporting

confidence: 79%

Isolation, identification and anti-candidal activity of filamentous fungi from Saudi Arabia soil

Al‐Enazi

Awaad

Al‐Othman

et al. 2018

Saudi Pharmaceutical Journal

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Ten fungal strains; namely, ,, ,, ,, ,, and were isolated from soil. The extra- and intra-cellular extracts of the fungal strains grown on malt extract and yeast-extract sucrose media were screened for their anticandidal activity against different clinically-isolated species. Most of the fungal extracts showed activity against different species. However, the fungal strains grew on malt extract showed greater activities than those grew on yeast extract sucrose media. The activity of the intracellular was higher than the extracellular metabolites. All fungal extracts (extra and intra) were similar in chemical constituent; they contained carbohydrates and/or glycosides, unsaturated sterols and/or triterpens, tannins and traces of coumarins. Alkaloids, flavonoids, saponins, anthraquinones and cardenolides were no detected. The intra-cellular extracts contained more compounds than the extra-cellular extracts.

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Section: Resultssupporting

confidence: 79%

Isolation, identification and anti-candidal activity of filamentous fungi from Saudi Arabia soil

Al‐Enazi

Awaad

Al‐Othman

et al. 2018

Saudi Pharmaceutical Journal

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“…Dry powder (830 and 795 g) of Galaxaura rugose and Liagora hawaiiana ; respectively, were extracted by percolation in 95% ethanol (Awaad et al, 2017a) at room temperature for two days. The total ethanol extract was filtered and the residue was re-percolated by the same manor for five times.…”

Section: Methodsmentioning

confidence: 99%

Biological activities of the red algae Galaxaura rugosa and Liagora hawaiiana butters

Al‐Enazi

Awaad

Alqasoumi

et al. 2018

Saudi Pharmaceutical Journal

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The biological activities; antimicrobial, antioxidant and anticancer, of the red algae and were determined. The total ethanol, lipoidal matters, chloroform, n-butanol, aqueous extracts and powder of both algae showed and bacterial and antifungal activities. However, the chloroform extract of showed antibacterial activity against (24 mm, 0.15 mg/ml) higher than gentamycin (23 mm, 0.49 mg/ml). Moreover, the total ethanol, lipoidal matter and chloroform extracts showed antifungal activity (21, 22 and 25 mm, 1.25, 0.312 and 0.156 mg/ml) similar to the antibiotic Ketoconazole activity (23, 24 and 27 mm, 1.25, 0.312 and 0.156 mg/ml) against , and , respectively. A good antioxidant activity (80.96%, IC = 27.8 µg/ml) was provided by . The anticancer activity results revealed that the lipoidal matters of and possessed antitumor activity (IC = 15 ± 1.7 and 21.2 ± 1.6, respectively) against lung carcinoma (A-549) better than vinblastine sulfate (IC = 24.6 ± 0.7). Although, the lipoidal matters of and antitumor activity against cervical carcinoma (HeLa) and intestinal carcinoma (CACO-2) (IC = 10.2 ± 0.6 and 12.2 ± 0.6, respectively) preferable than vinblastine sulfate (IC = 59.7 ± 2.1 and 30.3 ± 1.4, respectively).

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“…Lactobacillus spp. have been reported to inhibit the growth of Candida albicans and prevent the relapse of yeast infection [52]. The metabolite of Lactobacillus plantarum strain N4…”

Section: Antimicrobial Potentials Of Beneficial Microbes Against Antimentioning

confidence: 99%

Beneficial Microbes: Roles in the Era of Antimicrobial Resistance

Afolayan¹,

Adetoye²,

Ayeni³

2019

Antimicrobial Resistance - A Global Threat

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The upsurge of resistance in classes of antibiotics in varied bacterial species has increased the search for alternatives to antibiotics in bacterial infections. However, one alternative is the beneficial bacteria in foods, environment and gut. Probiotics is now being embraced as an alternative strategy to combat antibiotic resistant pathogens. A newer application is gut microbiota in its healthy state combating pathogenic and antibiotic resistant microbes. There have been numerous applications of beneficial bacteria against different infectious agents. This article describes the concept of beneficial microbes as antimicrobial agents with current applications as antimicrobial agents, various applications in the human gut with future directions.

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Amhezole, A Novel Fungal Secondary Metabolite fromAspergillus terreusfor Treatment of Microbial Mouth Infection

Cited by 18 publications

References 37 publications

Isolation, identification and anti-candidal activity of filamentous fungi from Saudi Arabia soil

Isolation, identification and anti-candidal activity of filamentous fungi from Saudi Arabia soil

Biological activities of the red algae Galaxaura rugosa and Liagora hawaiiana butters

Beneficial Microbes: Roles in the Era of Antimicrobial Resistance

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