AMH protects the ovary from doxorubicin by regulating cell fate and the response to DNA damage
Ngoc Minh Phuong Nguyen,
Eun Mi Chang,
Maeva Chauvin
et al.
Abstract:Anti-Mullerian hormone (AMH) protects the ovarian reserve from chemotherapy, and this effect is most pronounced with Doxorubicin (DOX). However, the mechanisms of DOX toxicity and AMH rescue in the ovary remain unclear. Herein, we characterize these mechanisms in various ovarian cell types using scRNAseq. In the mesenchyme, DOX activates the intrinsic apoptotic signaling pathway through p53 class mediators, particularly affecting theca progenitors, while co-treament with AMH halts theca differentiation and red… Show more
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