American Society of Nephrology Quiz and Questionnaire 2015: Glomerular Diseases

Abstract

The Nephrology Quiz and Questionnaire remains an extremely popular session for attendees of the annual Kidney Week meeting of the American Society of Nephrology. Once again, the conference hall was overflowing with audience members and eager quiz participants. Topics covered by the expert discussants included electrolyte and acid-base disorders, glomerular disease, ESRD/dialysis, and kidney transplantation. Complex cases representing each of these categories, along with single-best-answer questions, were prepared and submitted by the panel of experts. Before the meeting, training program directors of United States nephrology fellowship programs and nephrology fellows answered the questions through an Internet-based questionnaire. During the live session, members of the audience tested their knowledge and judgment on a series of case-oriented questions prepared and discussed by the experts. They compared their answers in real time using their cell phones with a special app with the answers of the nephrology fellows and training program directors. The correct and incorrect answers were then discussed after the results of the questionnaire were displayed. As always, the audience, lecturers, and moderators enjoyed this educational session. This article recapitulates the session and reproduces its educational value for Clinical Journal of the American Society of Nephrology readers. Enjoy the clinical cases and expert discussions.

Detection of N‑glycoprotein associated with IgA nephropathy in urine as a potential diagnostic biomarker using glycosylated proteomic analysis

“…According to the Oxford classification, endocapillary hyperplasia, interstitial cell hyperplasia, segmental glomerulosclerosis and tubular atrophy or interstitial fibrosis are considered independent predictors of prognosis for patients with IgAN (9)(10)(11). A major finding in patients with IgAN is the presence of circulating and glomerular immune complexes, including galactose-deficient IgA1, as IgG autoantibodies against hinge region O-glycans, and complement C3 (12). On the one hand, IgA-containing complexes cause renal damage mainly through glomerular inflammation and thylakoid hyperplasia.…”