“…considered too unwell for pct, although there are some notable exceptions: for example, small-cell lung cancer (sclc) is highly chemosensitive and rapidly responsive to therapy [7][8][9][10] . Indeed, in 2012, the American Society of Clinical Oncology published their top five recommendations to improve cancer care and reduce costs 11 , the first of which says "Do not use cancer-directed therapy for patients with solid tumors who have the following characteristics: low performance status (3 or 4), no benefit from prior evidence-based interventions, not eligible for a clinical trial, and with no strong evidence supporting the clinical value of further anticancer treatment." With that recommendation in mind, tools to identify patients who will not benefit from cytotoxic therapy are clearly useful.…”